Proven low drug binding
Specially formulated for critical fluid applications, Supor membrane’s low protein-binding characteristics provide minimal adsorption and superior bacterial retention.

Certified biologically safe
Supor membrane complies with United States Pharmacopoeia (USP25/NF20) Biological Reactivity Tests, In Vivo <88>, and ISO 10993 standard for externally communicating, circulating blood, extended-use devices. Supor membrane’s advanced formulation contains no external wetting agents or surfactants that might introduce unwanted extractables downstream of the filter.

Fast flow rates, long life
The highly porous membrane structure provides excellent filtration efficiency, outstanding flow rates, and high throughputs. The inherently hydrophilic membrane allows multiple-repriming capability.

Versatile
Supor membrane is available in a wide selection of pore sizes to meet the filtration requirements of applications ranging from antibiotic therapy to pain management.

Pall has undertaken extensive studies to evaluate Supor membrane adsorption characteristics with a variety of commonly infused and/or injected drugs. The following is a list of drugs Pall has studied, all of which are compatible with IV filter devices containing Supor membrane.

Generic Name
Acetazolamide sodium
Albumin
Ampicillin sodium
Bupivacaine hydrochloride
Cefoxitin
Cimetidine hydrochloride
Cisplatin
Dexamethasone sodium phosphate
Dobutamine hydrochloride
Dopamine hydrochloride
Doxorubicin hydrochloride
Ephedrine hemisulfate
Etoposide
5-Fluorouracil
Insulin
Lidocaine hydrochloride
Mannitol
Methotrexate sodium
Methyldopate hydrochloride
Metronidazole
Morphine sulfate
Nitroglycerin
Paclitaxel (Taxol®)
Penicillin G potassium
Procaine hydrochloride
Sodium citrate
Sodium nitroprusside
Sulfamethoxazole
Trimethoprim
Vidarabine
Vinblastine sulfate
Vincristine sulfate
Ceftriaxone soldium
Foscarnet sodium
Ganciclovir sodium
Nafcillin
Piperacillin
Tobramycin

Superior protection against endotoxins
Supor® IV filter devices were separately tested for bacteria associated endotoxin retention at differing challenge concentrations. At clinically significant endotoxin concentrations, 0.2 μm positively-charged IV filters were retentive. At gross-contamination concentrations, the Pall IV filters outperform the leading competitor.

Outstanding flow rates, limited flow decay over 96 hours
Twelve liters of a standard TPN solution were administered through gamma-sterilized devices for 96 hours. Maximal flow rates (mL/min) were measured initially and every 24 hours to determine flow decay. Flow rates for Pall IV filter devices at 96 hours were 22% greater than the leading competitor’s initial flow rates.

Patient protection against air embolism regardless of position
Primed Pall IV filter devices eliminate air at constant rates regardless of filter position. Air bubbles will not obstruct flow at any time; thus, no need to worry about patients rolling over and changing the position of the filter.

96-hour Brevundimonas diminuta Retention
Gamma-irradiated 0.2 μm Pall IV filter devices were challenged with Brevundimonas diminuta according to a modified ASTM F838-83 methodology for 96 hours. The filters retained the challenge organism for the entire 96-hour period.

Fast and easy priming
The time required to prime each filter device (expel the air within the housing) and begin flow with differing solutions and head heights were recorded. Pall IV filter devices consistently allow nurses to quickly prime IV lines and move to the next patient.

Retention of Candida albicans for 24 hours
Pall 1.2 μm Supor® IV filter devices were separately challenged with two differing concentrations of C.albicans, a commonly occurring fungal contaminant of lipid-containing total nutrient admixtures (TNA). Both the gross-contamination and touch-contamination challenges were retained for 24 hours.

Consistent flow rates for reliable and precise delivery of solutions
0.2 μm filtered water, at a 36-inch head height, was allowed to flow through Pall 0.2 μm IV filter devices. Flow rates were measured for one minute. The average flow rate for Pall devices was 29.4 mL/minute with a standard deviation of less than 1 mL/min.