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Cascada™ AN-Water System: Compliance With US Pharmacopoeia Purified Water Specification
  Cascada™ AN-Water System: Compliance With US Pharmacopoeia Purified Water Specification


Introduction
The Cascada AN-water System is fed with partially purified water. The unit produces extremely high ultrapure water for critical laboratory applications suitable for all analytical and pharmaceutical applications.

The product water comfortably exceeds the USP (29-NF24 2006) purified water specification.


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Results

Parameter
USP Purified Water
Specification
Typical Measured
Values
Conductivity (µS/cm at 25 °C)    < 1.3 0.055
TOC (ppb C) < 500 1.1 to 1.8
Bacteria (CFU/mL) < 100 < 1

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Method
A Cascada AN-water System was fed with reverse osmosis (RO) permeate water with a conductivity of 28 µS/cm and a TOC of 60 ppb. The unit was operated intermittently and product water dispensed to simulate typical use patterns.

Conductivity and TOC were logged online using a Thornton 200CR meter and a Sievers 820 TOC analyzer respectively. Samples were taken for bacterial analysis at various times.

Total viable counts were measured after membrane filtration and incubation at 27 °C for 5 days on R2A agar.


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