• High efficiency filtration provides consistently low residual leukocytes in processed RBC*, platelets and plasma.
• Enhanced RBC recovery by auto-drainage.*
• Allows for semi-automatic processing and filtration of the entire platelet rich plasma layer.
• Provides greater QC assurance of meeting platelet recovery requirements.

Make cGMP Compliance Easier Than Ever

• Fits into routine operating procedures without additional labeling and handling.
• Requires no sterile connection which eliminates the rework process of dockable leukoreduction and associated errors and product loss.
• Features easy, snap-open closures for fast opening of fluid paths between bags.

*Applies to Leukotrap RC PL System only.

1. Bruneau C, Perez P, Chassaigne M, Allouch P, Audurier A, Gulian C, Janus G, Boulard G, De Micco P, Salmi LR, Noel L. Efficacy of a new collection procedure for preventing bacterial contamination of whole-blood donations. Transfusion 41:74-81, 2001.

Figure 1. Consistency of performance with RCM1 and ATS LPL Filters using the Leukotrap® RC PL System

Data from actual field use.
Shown are mean residual WBC/unit and 95% confidence interval.

Greater QC Assurance of Platelet Recovery Requirements

Figure 2. Platelet yield distribution of individual platelet concentrates (PC) prepared using the Leukotrap RC PL System

Data from 500 mL WB (n=700) collections processed with the Leukotrap RC PL System.
Mean platelet yield = 8.87 x 10¹⁰ with a standard deviation of 2.42 x10¹⁰ platelets.
Ninety-two percent (92%) of PCs had a platelet count greater than the AABB Standards⁷ for platelets prepared from whole blood (>5.5 x 10¹⁰).

Figure 3. Platelet yield distribution of a pool of five (5) individual platelet concentrates (PC) prepared using the Leukotrap RC PL System

The distribution was obtained by computer simulation using the individual PC yield data shown in Figure 2.
Mean platelet yield with a pool of 5 = 4.3 x 10¹¹ with a standard deviation of 5.3 x 10¹⁰ platelets.
Over ninety-nine percent (99.6%) of the PC pools had a platelet yield greater than the AABB Standard for platelets prepared by cytapheresis⁸ (^>3.0 x 10¹¹).

7. Standards 5.7.5.15 and 5.7.5.15.1 - Standards for Blood Banks and Transfusion Services, AABB 21st Edition, 2002.
8. Standard 5.7.5.18 - Standards for Blood Banks and Transfusion Services, AABB 21st Edition, 2002.

“Since the implementation of the Pall RC PL system in our laboratory, I no longer have any concerns about the high quality of our leukoreduced red cells and whole blood derived platelets as finished products...We have experienced a marked increase in our platelet yields using the RC PL system. The techs are grateful to have products on the shelf already leukoreduced, which lessens the turnaround time in preparing the product for immediate patient transfusion.” Joan Doherty, Technical Supervisor

“The RC PL system was not difficult to learn. The process for making the platelet product may be longer than our previous process, but the final product is better for the patients.” Faith Lesser, Component Technician

“I was introduced to the RC PL system without having any prior component preparation experience. Within 48 hours I was able to perform the entire process on my own. I know the products I prepare are of good quality because we never have a problem passing monthly QC.” Karen Jones, Lab Processing Technician II

	1 Collection of whole blood into the primary bag.
	2 Load system into a centrifuge cup as illustrated. Use Leukotrap Strap or tape to secure filters in cup. Use standard centrifuge protocols.
	3 Carefully place separated unit into plasma expressor. Release expressor plate to put pressure on the primary bag. Insert the Pall ATSLPL filter in the Pall ATSLPL filter holder,* ensuring that the side labeled "OUT" faces up.
	4 Clamp tubing near the RCM1 filter. Open the transfer leg closure on the primary bag. When ATSLPL filter outlet side turns pink, clamp between the ATSLPL filter and Y connector.
	5 Seal off and remove the leukocyte reduced platelet rich plasma and ATSLPL filter. Seal off and discard ATSLPL filter.** Prepare platelet concentrate using standard protocols.
	6 Store platelet concentrates with agitation at 22 °C for up to 4 days and use as indicated.
	7 Within 8 hours of collection, with RCM1 filter in a vertical position, transfer additive solution (AS-3) to packed red cells. Clamp tubing close to bag containing AS-3 red cells and mix thoroughly.
	8 Hang the red blood cell unit. Remove clamp to allow the red cells to gravity flow through the RCM1 filter into the additive bag. If filtration is not complete within 8 hours of collection, finish filtration at 4 °C.
	9 Remove RCM1 filter and collection bag and discard.** Segment tubing and store the leukoreduced red cells at 1 - 6 °C for up to 42 days and use as indicated.

* Contact your Pall sales representative for an ATSLPL filter holder to meet your needs.
** Discard in a manner consistent with biohazardous waste disposal procedures.

• Leukotrap® Filtration Systems for Whole Blood Derived Platelets (Leukotrap RC PL and Leukotrap PL systems) Product Brochure
• Leukotrap® Systems with the Pall Sample Diversion Pouch: Blood Collection Instructions (Poster)

• An Acrodose^SM Platelet
• Pooling and Storing: Acrodose™ PL System
• Bacteria Detection and Management: Pall eBDS and Pall Data

For the full story, go to A New Platform for Platelet Transfusion Safety.