Drug Screening

The identification, optimization, and verification of new therapeutic compounds within the drug discovery pipeline is a long and expensive process. Scientists in research are constantly looking for solutions to run screens in shorter time with higher confidence.

AcroWell™ and AcroPrep™ filter plates are designed in accordance with the requirements of the Society of Biomolecular Screening (SBS) to ensure safe robotic processing. This will minimize offline handling times. A rigid polypropylene housing and a serial bar code on each plate warrant worry-free and completely traceable sample processing with automated stackers, grippers, and plate readers.

Unique, patented GH Polypro (GHP, hydrophilic polypropylene) membrane allows users to perform radio-labeled cell assays with much lower cell density than traditional glass fiber matrices. In addition, the same membrane has very low fluorescent background. This presents additional application possibilities for more sensitive fluorescent assays such as time-resolved fluorescence (TRF) assays used in PerkinElmer’s Delfia* System.

The large number of membranes and housing selections in 96- and 384-well configurations opens unlimited opportunities, including purification of combinatorial libraries, receptor:ligand assays, multiplexing assays such as Luminex* bead systems or even protein-drug binding assays using Omega™ ultrafiltration membranes.

*Delfia is a trademark of PerkinElmer, Inc. Luminex is a trademark of Luminex Software, Inc.

Drug Screening Product Selection Guide

Cell-based Assays

Pall recommends the following filter plates for cell-based assays:

• AcroWell Plates with GHP Membrane - White
• 350 µL and 1 mL AcroPrep 96 Plates with Glass Fiber - White
• AcroPrep 384 Plates with GHP Membrane

Bead-based Assays

Pall recommends the following filter plates for bead-based assays:

• AcroWell Plates with GHP Membrane - White
• 350 µL and 1 mL AcroPrep 96 Plates with GHP Membrane - Opaque, White, Black
• 350 µL and 1 mL AcroPrep 96 Plates with 1.2 µm Supor® PES Membrane
• 350 µL and 1 mL AcroPrep 96 Plates with 0.2 µm Bio-Inert® Membrane

Drug Binding Studies

Pall recommends the following filter plates for drug binding studies:

• 350 µL and 1 mL AcroPrep Ultrafiltration Membrane Plates - 10K, 30K, 100K
• AcroWell 96 Plates with BioTrace™ PVDF Membrane
• AcroWell 96 Plates with BioTrace NT Nitrocellulose Membrane

Kinase Assays

Pall recommends the following filter plates for kinase assays:

• AcroPrep 96 Plates with Mustang® S Membrane
• AcroWell 96 Plates with BioTrace PVDF Membrane

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