Membranes are recommended in chromatography applications when there is a need to purify large molecules or in situations where faster flow is needed. Membrane chromatography is extremely economical because flow rates are significantly faster than traditional resin chromatography, decreasing cycle time and increasing throughput. Pall's Mustang® membranes possess large convective pores and have dynamic binding capacities that are relatively insensitive to the effects of high flow rates, even for large molecules such as plasmids and viruses.

 Pall's membrane devices for ion exchange chromatography offer:

• True scaleability. For laboratory-scale applications, Mustang membranes are available in Acrodisc units for single samples and AcroPrep filter plates for higher sample processing. Devices with Mustang S and Mustang Q membranes can be scaled up to larger-capacity capsules and cartridges from Pall.
• Application-specific membrane chemistries. Mustang Q membrane is a strong anion exchanger that effectively binds plasmid DNA, negatively-charged proteins, and viral particles. Mustang S membrane is a strong cation exchanger that effectively binds positively-charged proteins and viral particles.
• High binding capacities and fast flow rates. Mustang membranes withstand high flow rates to render faster purification without affecting recovery rates.

Applications:

• Contaminant removal such as DNA viral particle, host cell proteins, or endotoxin.
• Isolation via capture and release of plasmid DNA, virus or target protein from a complex mixture.
• Protein fractionation or capture.
• Antibody purification.