Chromatography Columns for Process Development and Optimization
Pall offers a comprehensive line of chromatography columns for lab to process scale including:
PRC 1 mL and NEW 5 mL
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PRC 1 mL and 5 mL prepacked columns are available in chemistries for mixed mode and ion exchange chromatography. Rapid screening and condition optimization in the 1 mL PRC column enables rapid selection of the appropriate chemistry. Once the chemistry is selected on a 1 mL PRC column, the conditions of use can be optimized in a 5 mL PRC column in doubling the height. Two or more columns can be connected in series to increase the column height and more closely model real conditions in pilot scale or for scale down applications. Choose:Acrosep™ 1 mL Pre-Packed Chromatography Columns are also available to simplify protein purification and fractionation for biomarker discovery, proteomics research, and drug development in laboratory applications.
LRC Chromatography Columns
LRC chromatography columns are empty glass columns that accommodate sorbent volumes up to 900 mL for preparative and process optimization applications. The are designed to enable easy scale-up of any biochromatography step. |
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Resolute FM Chromatography Columns for Pilot Scale
Resolute FM columns are ideal for chromatographic purification from process development through to manufacturing scale with a wide range of commonly used media. These glass, columns for development and manufacturing applications, are robust and incorporate new features to improve the outcome of column packing events. The industry accepted constant compression seal design used in the successful Resolute DM range is also incorporated in the FM series.Features and Benefits
- Unique constant compression adjuster seal simplifies column operation
- Low friction adjuster mechanism enables packing compression to x1.2cf
- Easy air removal prior to packing for first time packing event
- Improved safety with an adjuster that enables packing without removal from column
- Low pressure drop flow path supports high linear velocity up to 700 cm/hr for maximum productivity
- Simple maintenance of seals and nets with quick and easy removal of both distributor plates without use of special tools
- Hygienic design suitable for effective sanitization
- Precision borosilicate glass tube and stainless steel flow path provides excellent chemical compatibility
- Scale up with 3 column sizes 100, 140 and 200 mm diameter with capacities from 0.78 L to 8.4 L
Resolute DM, DP, and DAP Chromatography Columns for Production
- Optimal process chromatography at manufacturing scale from 280 mm to 2000 mm diameter
- Reduced cost of ownership by minimizing buffer usage and labor
- Reliable, reproducible, scalable performance
Resolute Chromatography Columns are ideally suited for process purification in the biopharmaceutical industry. Three-position nozzle valves provide all column functions required for packing, unpacking and running of the column in a closed system. Resolute columns provide excellent improved column performance, cleanability and true linear scalability combined with reproducible column packing methods for today’s high performance sorbents.
The packing process is supported by a Resolute Slurry Packing System which, combined with the Dynamic Axial Packing (DAP) hydraulic option on Resolute columns, offers a complete flexible, long-term solution to scale up process chromatographic purification from development to manufacturing.
Integrated systems for scalable packing and unpacking of process chromatography columns. Resolute™ slurry packing systems (SPS) are optimized for use with Resolute chromatography columns. With the flexibility of four systems in the series, column packing and unpacking can be optimized for one or multiple columns up to 2000 mm diameter.
The combined features of Resolute columns provide the most cost-effective technology for performing chromatographic purification to enhance your process economics.
- Reproducible packed bed performance without repacking events
- Reduced downtime with fast access for simple seal and bed support replacement
- Efficient distribution system reduces Clean-In-Place (CIP) chemical and buffer consumption
Based on performance by design, Resolute columns will improve operating costs through reduced buffer usage and manpower while providing a technology that is flexible in order to meet your process needs for the foreseeable future, even with the most challenging sorbents.
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