Pall Chromatography Sorbents

Pall offers a comprehensive, versatile and environmentally-friendly range of chromatography sorbents that greatly simplifies protein purification challenges from lab to process scale.  Pall chromatography sorbents can improve the downstream purification accuracy, speed, safety, reliability, and decrease purification cost. Sorbent chemistries include:  Ion Exchange Mixed Mode Hydroxyapatite Affinity Size Exclusion Solvent-detergent Removal and HIC Ion-Exchange Chromatography Sorbents Pall provides a complete range of ion exchange chromatography sorbents that answer protein capture, purification and polishing challenges. NEW Q and S HyperCel™ Sorbents Q and S HyperCel sorbents represent the latest generation of PALL industry-scalable ion exchangers designed for high productivity capture and intermediate separation steps. Based on the robust and chemically-stable HyperCel base matrix, these ion exchangers offer different selectivities and salt sensitivity for protein elution, and have outstanding dynamic binding capacities at short residence times (1 or 2 minutes). Also available in PRC Prepacked Q and S HyperCel Columns for fast selectivity screening.  Q, S, DEAE and CM Ceramic HyperD® F Sorbents Ceramic HyperD® 'gel-in-a-shell' sorbents are rigid, non-compressible sorbents with excellent pressure/flow characteristics that operate two to five times faster than conventional soft gels, and significantly increase the speed and throughput of ion-exchange chromatography steps. Also available in PRC Prepacked Q and CM Ceramic HyperD® F Columns for fast selectivity screening.

See also Mustang® Ion Exchange Membrane Devices.

Mixed-Mode Chromatography Sorbents

Mixed-mode or multi-mode chromatography exploits different ligand-protein interaction mechanisms and provide new selectivitites  for protein separations, different from ion- exchange or hydrophobic interaction chromatography. The Pall® mixed-mode sorbent family includes MEP HyperCel™, HEA HyperCel™ and PPA HyperCel™ sorbents, based on robust synthetic ligands immobilized on an industry-scalable matrix. They provide innovative selectivities for protein purification. Based on an industry-scalable robust matrix, MEP, HEA and PPA HyperCel sorbents can be used from laboratory to production scale columns, and are available in convenient, prepacked PRC columns for selectivity screening.  

MEP HyperCel™ Chromatography Sorbent
MEP HyperCel™ sorbent is immunoglobulin-selective and can be applied for capture or intermediate purification of monoclonal antibodies.

HEA HyperCel™ and PPA HyperCel™ Chromatography Sorbents
HEA and PPA HyperCel sorbents are novel industry-scalable chromatography sorbents designed for protein capture and impurity removal in a biopharmaceutical environment. Also available in PRC Prepacked MEP, HEA and PPA HyperCel™ Columns for fast selectivity screening. PRC prepacked columns have a sorbent volume of 1 mL, are ready and easy-to-use and guarantee optimal and consistent performance.

Hydroxyapatite Chromatography Sorbents

HA Ultrogel® Hydroxyapatite Chromatography Sorbent 
HA Ultrogel hydroxyapatite chromatography sorbent is a hydroxyapatite agarose composite sorbent for the separation of biomolecules from research and development scale to manufacturing.

Affinity Chromatography Sorbents

Blue Trisacryl® M Affinity Chromatography Sorbent
An affinity chromatographic sorbent used for the purification of a wide variety of enzymes and proteins such as kinases, albumin, interferons and some coagulation factors.

Heparin HyperD® M Affinity Chromatography Sorbent
The most technologically advanced, high-speed, high-capacity affinity preparative sorbent for the purification of biological molecules that bind to heparin, such as coagulation factors, growth factors, and lipoproteins.

Protein A Ceramic HyperD® F Affinity Chromatography Sorbent
This affinity chromatography sorbent is a high-capacity affinity sorbent designed for process-scale purification of immunoglobulins G. The sorbent combines ease of use with high binding capacity and excellent scalability.

Lysine HyperD® Affinity Chromatography Sorbent
Lysine HyperD® sorbent is a high-speed, high-capacity affinity preparative sorbent for the purification of biological molecules that bind to lysine, such as plasminogen from human or animal species plasma. The sorbent provides high binding capacity at high flow rates.

Size Exclusion Chromatography Sorbents

Trisacryl® GF05 M, LS Size Exclusion Chromatography Sorbent
Composed of a highly-hydrophilic copolymer, designed for medium-pressure gel filtration chromatography. It is ideal for desalting and for the separation of small molecules.

Ultrogel® AcA Size Exclusion Chromatography Sorbents
These sorbents are a range of composite sorbents for size exclusion of biological macromolecules. They consist of polyacrylamide and agarose gel matrix and possess good mechanical and chromatographic properties when compared to classical size exclusion sorbents.

Solvent Detergent Removal and HIC Chromatography Sorbents

SDR HyperD® Solvent-Detergent Removal Chromatography Sorbent
SDR HyperD® is a unique sorbent, designed to eliminate solvent and detergent from biological fluids.

Methyl Ceramic HyperD® F Hydrophobic Interaction Chromatography Sorbent
Designed for efficient and scalable capture of biomolecules by mild hydrophobic interaction chromatography.

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