MEMBRAplan® DGM Plate and Frame Filter System

With the MEMBRAplan® DGM Filter Press System, a new generation of sheet filters was developed, setting new standards for modern pharmaceutical and biotechnological  production. It can be used for a wide range of applications from initial cell harvest to downstream clarification steps.

The MEMBRAplan DGM Filter Press System is a multiple-sheet filter system for filtration with depth filter sheets. It is the first system of its kind, allowing for complete Clean-In-Place (CIP) cleaning and sterilization, and thus meeting all requirements for pharmaceutical equipment.

The key to the success of the MEMBRAplan DGM Filter Press System lies in the unique design of the filter plates. Each filter plate is sealed with an O-ring at the outer edge of the plate. This allows for zero leakage from the filter press during processing and CIP cleaning, and eliminates any product contact with the surrounding environment.

The MEMBRAplan DGM Filter Press System is available as a plate-and-frame system (DG) or as a plate-and-frame system with mechanical dehydration (DGM) design. The DGM version allows for mechanical squeezing of the filter cake with an elastic membrane, thus increasing yields by reduction of moisture in the solids. This results in a dry and compact filter cake, which can be easily removed from the frame.

Features and Benefits

• Totally enclosed sheet filter system eliminating undesirable product loss
• Enclosed design allows for CIP cleaning and Steam-In-Place (SIP)* sterilization
• Mechanical dehydration (DGM) ensures higher yield and reduction of residual moisture in the filter cake
• Mechanical dehydration (DGM) allows for a dry, compact cake in a short time when compared to typical gas drying
• Utilizes standard depth filter sheets for maximum selectivity
• Sizes from 300 x 300 mm (11.8 x 11.8 in.) to 1000 x 1000 mm (39.3 x 39.3 in.) for maximum scalability
• Cake washing plates available for maximum product recovery
• Can be equipped with automatic plate shifters and cleaning portals for 800 x 800 mm (31.4 x 31.4 in.) and 1000 x 1000 mm (39.3 x 39.3 in.) designs
• Filter plate and frames materials in USP-certified polypropylene or 316 stainless steel

* (Stainless steel version only)

• Plasma fractionation
• Cell harvest
• Clarification of therapeutical proteins, vaccines, diagnostics, enzymes and antibiotics
• Removal of activated carbon
• Removal of filter aids
• Removal of catalysts

Due to the enclosed design of the MEMBRAplan DGM system, for the first time a complete Clean-In-Place (CIP) cleaning can be carried out, which - in combination with manual precleaning - guarantees the reproducibility of the cleaning method by the FDA Inspection Guide on Cleaning Validation.

The filer plate design was specially developed for strict requirements on hygiene and cleanliness in the biotechnological and pharmaceutical industry, taking the recommendations and regulations of FDA, GMP and 3-A into consideration. Closing of the filter pack is carried out via hydraulic cylinder with mechanical locking. The pneumatically operated hydraulics are installed on the cross member and are explosion-proof as standard (no electrical components).

MEMBRAplan DGM	DG Filter Press	DGM Plate and Frame
Size	300 = 300 x 300 mm (11.8 x 11.8 in.) 400 = 400 x 400 mm (15.7 x 15.7 in.)	600 = 600 x 600 mm (23.6 x 23.6 in.) 800 = 800 x 800 mm (31.4 x 31.4 in.) 1000 = 1000 x 1000 mm (39.3 x 39.3 in.)
Materials	K = Polypropylene	P = Stainless Steel
Chassis Size	30 50	60 100 150 200

Please contact Pall Corporation for additional technical information for sizing and selection of the correct MEMBRAplan DGM filter press system

Please contact Pall Corporation or your local representative for information on the MEMBRAplan DGM filter press system.