Q, S, DEAE and CM Ceramic HyperD® F Chromatography Sorbents

Introduction

Q, S, DEAE and CM Ceramic HyperD® F chromatography sorbents are designed using Pall’s proprietary 'gel-in-a-shell' design that provides rapid mass transfer and effective binding.

It relies on a high capacity hydrogel, polymerized within the gigapores of a rigid ceramic bead.

Features and Benefits

• High dynamic binding capacity for proteins
• Non-compressible, excellent pressure/flow characteristics
• Significantly increase the productivity of ion exchange capture and purification
• Validated for regulatory approved processes

Sorbent Applications

• Recombinant proteins
• Plasmid purification
• Purification of enzymes, plasma proteins
• Vaccines
• Direct capture of monoclonal antibodies (CM Ceramic HyperD® F)
• IgM

Sorbent Specifications

Item	Q Sorbent	S Sorbent	DEAE Sorbent	CM Sorbent
Average particle size (µm)	50	50	50	50
Ionic groups (µEq/mL)	> 250	> 150	> 200	250 - 400
Dynamic Binding Capacity (mg/mL) 10% breakthrough at 200 cm/hr	> 85¹	> 75²	> 85¹	> 60³
Working pH	2 -12	2 -12	2 -12	2 -12
Cleaning pH	1 - 14	1 - 14	1 - 14	1 - 14
Working pressure	< 2 bar	< 2 bar	< 2 bar	< 2 bar

¹ 5 mg/mL BSA in 50 mM Tris-HCl, pH 8.6; ² 5 mg/mL Lysozyme in 50 mM sodium acetate , pH 4.5; ³ 5 mg/mL hu IgG in 50 mM sodium acetate, 100 mM NaCl, pH 4.7

Sorbent Ordering Information

Size	Q Sorbent	S Sorbent	DEAE Sorbent	CM Sorbent
5 mL	20066-098	20062-089	20062-055	20050-084
25 mL	20066-031	20062-030	20067-039	20050-035
100 mL	20066-023	20062-022	20067-021	20050-027
1 L	20066-015	20062-014	20067-013	20050-019
5 L	20066-064	20062-048	20067-054	20050-050
10 L	20066-056	20062-055	20067-047	20050-043

Pre Packed Column	Order Number	Size
PRC Column 5x50 Q Ceramic HyperD F	PRC05X050QCHDF01	Content: 1 mL of sorbent
PRC Column 5x50 CM Ceramic HyperD F	PRC05X050CMCHDF01	Content:  1 mL of sorbent