HPLC and Chromatography Sample Preparation

Pall's Superior Media Separation Technology Ensures:

• Accurate pore size ratings for better chromatography and instrument and column protection.
• Uniform membrane materials (lot-to-lot) for consistent analytical results.
• Low extractable materials for less chromatographic interference.
• Materials of construction selected specifically for analytical analysis with lower extractables and lower API (Active Pharmaceutical Ingredients) adsorption.

Exceptionally Low Extractable Levels

A filter is designed to increase accuracy by removing unwanted particles. However, the wrong filter can be a source of contaminants called extractables that elute into the sample from the filter device. These undesired artifacts jeopardize analytical results. Some extractable concerns include coelution, false quantitation, and extraneous peaks.

The specific quality of raw materials, amount of quality control, membrane extraction procedures, and post-treatments all affect the resultant membrane properties and amount of extractable materials. Pall specifically selects the highest grade of materials and performs rigorous extraction methods on our membrane products to hinder the occurrence of undesired artifacts. Choosing membranes that are compatible with your fluids and experimental conditions will reduce/eliminate extractables. More about extractables...

Certified Syringe Filters

Pall's HPLC certification ensures that analytical results will not be compromised by extractable filter materials. To verify low levels of UV-detectable extractables, samples of the entire HPLC Acrodisc PSF syringe filter line are randomly taken and tested for compatibility with common solvents using HPLC (does not include HT Tuffryn®, Versapor® or Supor® membrane versions).

Pall certifies Ion Chromatography (IC) Acrodisc PSF syringe filters have been tested using a highly sensitive IC protocol to monitor inorganic extractables. Actual background levels of filter extractables are typically less than 20 ppb for chloride, 6 ppb for nitrate, 1 ppb for phosphate, and 10 ppb for sulfate.

Analytical Sample Prep Products for a Range of Applications and Tests

Applications	Tests	Applicable Filtration Products
Pharmaceutical Finished Product	Tablet Pre-formulation, Candidate Evaluation, Tablet and Capsule Assay, Tablet Stability, Drug Assay, Blend Uniformity, Dissolution Testing, Dosage Form Development, Particulate Removal, Sample Clarification	Acrodisc PSF Syringe Filters, Acrodisc Syringe Filters, Membrane Disc Filters
Pharmaceutical Raw Materials, Food and Beverage	Analytical Sample Preparation	Acrodisc PSF Syringe Filters, AcroPrep 24 Filtration System, AcroPrep 96 Filter Plates, Nanosep® MF Centrifugal Devices, SolVac Filter Holder, Glass Filter Funnels, Membrane Disc Filters
HPLC	Analytical Sample Preparation, Mobile Phase Filtration	Acrodisc PSF Syringe Filters, AcroPrep 24 Filtration System, AcroPrep 96 Filter Plates, Nanosep MF Centrifugal Devices, SolVac Filter Holder, Glass Filter Funnels, Membrane Disc Filters
UHPLC	Analytical Sample Preparation	Acrodisc and Acrodisc Syringe Filters with GHP, PVDF, Nylon, PTFE, and IC Membrane
Ion Chromatography	Analytical Sample Preparation	Acrodisc PSF Syringe Filters with IC Membrane, Acrodisc Syringe Filters with IC Membrane
GC	Analytical Sample Preparation	Acrodisc PSF Syringe Filters with PTFE Membrane, Acrodisc Syringe Filters with PTFE Membrane

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