Use of Acrodisc® Syringe Filters for Analytical Sample Preparation, Including HPLC and Dissolution Testing

Pall Life Sciences offers a broad range of analytical sample preparation products to protect your analytical instruments and ensure the integrity of your analytical results.

Within this Technical Guide, you'll find Pall quality certifications, performance studies, and useful selection criteria to help you choose the right product for your situation and provide documentation for its use in your lab. This technical guide is also ideal for reviewing filtration requirements and performance criteria with new lab personnel.

This extensive information is designed to move your research forward and help you run a more efficient lab.

We hope you find this tool useful in your lab. For further assistance, contact your local Pall Life Sciences Technical Service department.

The technical guide is divided into several useful sections.

• Pall's product quality assurance and certifications reassure you of our commitment to detail.
• Why filtration is necessary.
• Main considerations for choosing the best filter for your application.
• Improving HPLC column life by as much as 46 times through accurate pore size ratings.
• Minimizing the occurrence of extractables for less chromatographic interference.
• Reducing API (active pharmaceutical ingredients) adsorption.

Features and Benefits for Pall Life Sciences' Products

Feature	Benefit
Pall Life Sciences is a cGMP compliant facility and ISO 9001 certified.	Superior quality systems in place to ensure highest quality products consistently.
Acrodisc PSF is available with single-layer or built-in multi-layered glass fiber prefilter.	Easier filtration of difficult-to-filter solutions.
Acrodisc PSF is designed for automation and Automation Certified by Caliper Life Sciences. Packaged with AutoPack™ packaging.	Provides reliable and consistent performance in automated applications. Filters can be placed directly on the Caliper Life Sciences workstations.
Acrodisc filters are designed for high operating pressures with an integral membrane seal.	Assures high retention efficiency and housing will not burst during use.
Acrodisc filters offer better retention efficiency.	Longer HPLC column life. Less HPLC maintenance. Less chromatographic interference.
Available with HPLC certification or IC certification.	More consistent chromatography with less extractable interference.
Pall Corporation is the largest membrane manufacturer in the world.	We maintain control over membrane manufacturing to assure consistent membrane with the highest quality at all times. We have 50,000 material combinations to find a solution for every customer's needs.
Pall sells products into all aspects of the drug development pipeline from discovery to delivery.	We fully understand customers’ needs and requirements, and share that knowledge across divisions. We are regularly audited by the FDA, and large pharmaceutical and biotechnology companies, with no “483’s” in over ten years of successful audits.

Materials of Construction

HPLC & IC Certified Syringe Filters

Housing
Pure polypropylene

Media
Nylon: hydrophilic nylon
PVDF: hydrophilic polyvinylidene fluoride
PTFE: hydrophobic polytetrafluoroethylene
GHP: hydrophilic polypropylene
IC: Supor®, hydrophilic polyethersulfone
Glass Fiber: hydrophilic borosilicate glass fiber

Fittings
Female luer lock inlet; standard male luer or minispike outlets