Supor® EKV Membrane Filters
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Cost-Effective Filtration of Buffers, Tissue Culture Media, and Other Biological Fluids
- Disposable – Reduces labor costs associated with assembling, cleaning, and testing stainless steel filter holders.
- Flexible – Encapsulated format for ease of use.
- Extended life – Built-in MachV asymmetric prefilter layer for maximum flow and throughput performance.
- Simplified scale-up – Membrane and housing materials are identical to those used in larger-volume capsules and cartridges from Pall Life Sciences.
- Low adsorption and high chemical compatibility – Featuring hydrophilic polyethersulfone membrane for high compatibility over the entire pH range and low protein binding.
- Presterilized – Using gamma irradiation, products are presterilized, non-pyrogenic, and non-cytotoxic (with the exception of 47 mm disc filters).
- Inherently hydrophilic – Provides a reliable integrity test.
- Tested – Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>. Assessed during manufacture to ensure product integrity.
47 mm Disc Filters
- High throughput
- Low protein binding
- Fast flow rates
Applications
Suitable for sterile filtration of a wide range of fluids, including:- Buffers
- Biological fluids
- Cell culture media
- Ophthalmic products
AcroPak 20 Filters
- Designed to add convenience to small- and mediumvolume filtration
- Generates twice the effective filtration area and double the throughput/flow rate of conventional metal 47 mm reusable filter holders
- Disposable for reduced labor
- Significantly reduces the cost of repeat testing when scaling up your filtration system
Applications
- Ideal for filtering aqueous solutions, cell culture media, and serum
- Small- to medium-volume sterile filtration, typically up to 1 liter
- Suitable for use with fluids containing dilute proteins, preservatives, or other critical components
- Sterile filtration of media and buffers
25 mm Acrodisc® Syringe Filters
- Universal life science membrane with low protein binding to minimize sample loss
- Superior flow rates and higher throughputs than similar devices
- Sterilized by gamma irradiation to eliminate potential contamination by EtO residuals
Applications
- Small-volume applications (such as liquid sterilization and determination of product compatibility and recovery)
- Ideal for typical process volume up to 100 mL
AcroPak 200 Capsules
- High filtration area and compact size are ideal for upscale trials
- Minimal hold-up volume
- Good wettability for reliable integrity test
- United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>
- Sealed membrane and housing uses fusion technology to eliminate potential extractables
- Gamma sterilized, non-pyrogenic, and provided with a removable filling bell (except sanitary flange option)
- Hydrophilic polyethersulfone membrane for low adsorption and wide chemical compatibility
- Very high flow rates and consistently higher total solution throughputs due to superior porosity over other membranes
Applications
- Designed to quickly process difficult-to-filter solutions within 5-21 liters, such as serum, serum-supplemented culture media, and ascites fluid
- Ideal in situations where rapid filtration or short processing times are essential
AcroPak 400, 800 and 1500 Capsules
- Encapsulated format for higher flexibility, minimized cleaning, and low installation costs
- Minimal hold-up volume
- Hydrophilic polyethersulfone membrane for low adsorption and wide chemical compatibility
- Good wettability for a reliable integrity test
- Patented Ultipleat technology for high area and good flow rates
- Built-in MachV asymmetric prefilter layer for long-life and low filtration costs
Applications
Suitable for sterile filtration of a wide range of fluids, including:- Buffers
- Biological fluids
- Cell culture media
- Ophthalmic products
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47 mm Disc Filters with Supor EKV Membrane |
| Filter Media | Supor EKV membrane (hydrophilic polyethersulfone) |
| Pore Size | 0.2 μm |
| Effective Filtration Area | 9.6 cm2 (1.4 in.2) (dependent on holder |
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25 mm Acrodisc Syringe Filterswith Supor EKV Membrane |
| Filter Media | Supor EKV membrane (hydrophilic polyethersulfone) |
| Housing, Vent Plug, and Support Material | Polypropylene |
| Pore Size | 0.2 μm |
| Effective Filtration Area | 2.8 cm2 |
| Dimensions | Length: 21 mm (0.8 in.) Diameter: 29 mm (1.2 in.) |
| Inlet/Outlet Connections | Female luer lock inlet, male slip luer outlet |
| Typical Hold-up Volume (with Air Purge) | < 100 μL |
| Maximum Operating Temperature* | 60 ºC (140 ºF) at 2.1 bar (210 kPa, 30 psi) |
| Maximum Operating Pressure* | 5.4 bar (540 kPa, 80 psi) at ambient temperature |
| Recommended Integrity Test Minimum Bubble Point (Water) | > 3.32 bar (332 kPa, 48 psi) |
| Bacterial Retention | Lot samples retain a minimum of 107 cfu/cm2 of B. diminuta per modified ASTM F838, current revision |
| Endotoxin Level | < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test |
| Biological Safety | Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> |
| Sterilization | Sterilized by gamma irradiation and individually packaged |
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AcroPak 20 Filters with Supor EKV Membrane |
| Filter Media | Supor EKV membrane (hydrophilic polyethersulfone) |
| Housing, Vent Plug, and Support Material | Polypropylene |
| Filling Bell | Polycarbonate |
| Sealing Technology | Thermal bonding without adhesives |
| Pore Size | 0.2 μm |
| Effective Filtration Area | 20 cm2 |
| Dimensions | Length: 83 mm (3.3 in.) Diameter: 67 mm (2.7 in.) |
| Inlet/Outlet Connections | Stepped hose barbs, 6.4-12.7 mm (1/4-1/2 in.) diameter with female slip luer ID in the hose barb |
| Typical Hold-up Volume (with Air Purge) | < 2.5 mL |
| Maximum Operating Temperature* | 60 ºC (140 ºF) at 1.0 bar (100 kPa, 15 psi) at 21-24 ºC (70-75 ºF) |
| Maximum Operating Pressure* | 4.1 bar (410 kPa, 60 psi) |
| Recommended Integrity Test Minimum Bubble Point (Water) | > 3.32 bar (332 kPa, 48 psi) |
| Bacterial Retention | Lot samples retain a minimum of 107 cfu/cm2 of B. diminutaper modified ASTM F838, current revision |
| Endotoxin Level | < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test |
| Biological Safety | Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> |
| Sterilization | Sterilized by gamma irradiation or sold non-sterile; if desired, autoclave once at 125 ºC (257 ºF) for 60 minutes; water wet capsule prior to autoclaving |
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AcroPak 200 Capsules with Supor EKV Membrane |
| Filter Media | Supor EKV membrane (hydrophilic polyethersulfone) |
| Housing, Vent Plug, and Support Material | Polypropylene |
| Filling Bell | Polycarbonate (No filling bell on sanitary flange option) |
| Sealing Technology | Thermal bonding without adhesives |
| Pore Size | 0.2 μm |
| Effective Filtration Area | 220 cm2 |
| Dimensions | Housing Length 12094: 10.5 cm (4.1 in.) 12095: 7.3 cm (2.9 in.) Housing Diameter 5.3 cm (2.1 in.) without vent 6.7 cm (2.6 in.) with vent |
| Inlet/Outlet Connections | 12460: 25-38 mm (1-1.5 in.) sanitary flange inlet/outlet connection 12461: 13 mm (1/2 in.) hose barb inlet/outlet connection |
| Typical Hold-up Volume (with Air Purge) | < 6 mL |
| Maximum Operating Temperature* | 60 ºC (140 ºF) at 2.1 bar |
| Maximum Operating Pressure* | 4.1 bar (410 kPa, 60 psi) at ambient temperature |
| Recommended Integrity Test Minimum Bubble Point (Water) | > 3.32 bar (332 kPa, 48 psi) (210 kPa, 30 psi) |
| Typical Water Flow Rate | 350 mL/min/0.1 bar (241 mL/min/psi) |
| Bacterial Retention | Lot samples retain a minimum of 107 cfu/cm2 of B. diminutaper modified ASTM F838, current revision |
| Endotoxin Level | < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test |
| Biological Safety | Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> |
| Sterilization | Sterilized by gamma irradiation and individually packaged; if desired, autoclave once prior to use at 131 ºC (268 ºF) for 30 minutes; water wet capsule prior to autoclaving |
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AcroPak 400 Capsules with Supor EKV Membrane |
| Filter Media | Supor EKV membrane (hydrophilic polyethersulfone) |
| Housing, Vent Plug, and Support Material | Polypropylene |
| Filling Bell | Polycarbonate (No filling bell on sanitary flange option) |
| Sealing Technology | Thermal bonding without adhesives |
| Pore Size | 0.2 μm |
| Effective Filtration Area | 375 cm2 |
| Dimensions | Housing Length 12460: 11.7 cm (4.6 in.) 12461: 15.7 cm (6.2 in.) Housing Diameter (including valves) 9.4 cm (3.7 in.) |
| Inlet/Outlet Connections | 12460: 25-38 mm (1-1.5 in.) sanitary flange inlet/outlet connection 12461: 13 mm (1/2 in.) hose barb inlet/outlet connection |
| Maximum Operating Temperature* | 40 ºC (104 ºF) at 4.0 bar (400 kPa, 58 psi) |
| Maximum Operating Pressure* | 5.2 bar (520 kPa, 75 psi) at 20 ºC (68 ºF) |
| Recommended Integrity Test Minimum Bubble Point (Water) | > 3.32 bar (332 kPa, 48 psi) |
| Typical Water Flow Rate | 700 mL/min/0.1 bar (483 mL/min/psi) |
| Bacterial Retention | Lot samples retain a minimum of 107 cfu/cm2 of B. diminutaper modified ASTM F838, current revision |
| Endotoxin Level | < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test |
| Biological Safety | Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> |
| Sterilization | Sterilized by gamma irradiation and individually packaged |
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AcroPak 800 Capsules with Supor EKV Membrane |
| Filter Media | Supor EKV membrane (hydrophilic polyethersulfone) |
| Housing, Vent Plug, and Support Material | Polypropylene |
| Filling Bell | Polycarbonate (No filling bell on sanitary flange option) |
| Sealing Technology | Thermal bonding without adhesives |
| Pore Size | 0.2 μm |
| Effective Filtration Area | 750 cm2 |
| Dimensions | Housing Length 12463: 15.7 cm (6.2 in.) 12464: 19.7 cm (7.7 in.) Housing Diameter (including valves) 9.4 cm (3.7 in.) |
| Inlet/Outlet Connections |
12463: 25-38 mm (1-1.5 in.) sanitary flange inlet/outlet connection |
| Maximum Operating Temperature* | 40 ºC (104 ºF) at 4.0 bar (400 kPa, 58 psi) |
| Maximum Operating Pressure* | 5.2 bar (520 kPa, 75 psi) at 20 ºC (68 ºF) |
| Recommended Integrity Test Minimum Bubble Point (Water) | > 3.32 bar (332 kPa, 48 psi) |
| Typical Water Flow Rate | 1.5 L/min/0.1 bar (1.0 L/min/psi) |
| Bacterial Retention | Lot samples retain a minimum of 107 cfu/cm2 of B. diminutaper modified ASTM F838, current revision |
| Endotoxin Level | < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test |
| Biological Safety | Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> |
| Sterilization | Sterilized by gamma irradiation and individually packaged |
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AcroPak 1500 Capsules with Supor EKV Membrane |
| Filter Media | Supor EKV membrane (hydrophilic polyethersulfone) |
| Housing, Vent Plug, and Support Material | Polypropylene |
| Filling Bell | Polycarbonate (No filling bell on sanitary flange option) |
| Sealing Technology | Thermal bonding without adhesives |
| Pore Size | 0.2 μm |
| Effective Filtration Area | 1500 cm2 |
| Dimensions | Housing Length 1246: 17.4 cm (6.8 in.) 12467: 21.0 cm (8.3 in.) Housing Diameter (including valves) 10.5 cm (4.1 in.) |
| Inlet/Outlet Connections | 12466: 25-38 mm (1-1.5 in.) sanitary flange inlet/outlet connection 12467: 13 mm (1/2 in.) hose barb inlet/outlet connection |
| Maximum Operating Temperature* | 40 ºC (104 ºF) at 4.0 bar (400 kPa, 58 psi) |
| Maximum Operating Pressure* | 5.2 bar (520 kPa, 75 psi) at 20 ºC (68 ºF) |
| Recommended Integrity Test Minimum Bubble Point (Water) | > 3.32 bar (332 kPa, 48 psi) |
| Typical Water Flow Rate | 3.2 L/min/0.1 bar (2.2 L/min/psi) |
| Bacterial Retention | Lot samples retain a minimum of 107 cfu/cm2 of B. diminutaper modified ASTM F838, current revision |
| Endotoxin Level | < 0.25 EU/mL using Limulus Amoebocyte Lysate (LAL) test |
| Biological Safety | Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> |
| Sterilization | Sterilized by gamma irradiation and individually packaged |