Cord Blood Freezing Bag

For the long-term storage of 25 mL of cryopreserved, concentrated blood components. Each sterile set consists of a two-compartment, three-dimensional 25 mL freezing bag and a tubing lead terminating in a spike. The freezing bag has been designed to assure a homogenous, controlled freezing rate for maximum cell viability. The design simultaneously reduces the possibility of bag breakage from thermal, dynamic or expansion forces.

Freezing bag is compliant with AABB Standard for integral segments cryopreserved with product, enabling additional testing prior to transfusion.

Two separable compartments allow for a 4:1 division of contents, allowing a consistent volume aliquot for ex vivo cell expansion.

Compatible with liquid nitrogen (LN2) storage. Three-dimensional bag design ensures a homogenous, controlled freezing rate for maximum cell viability.

Freezing bag is uniquely compatible with DMSO/Dextran and liquid nitrogen storage in ThermoGenesis Corporation’s BioArchive^* System.

Compatible with the Cell Wash/Infusion Bag Set (PN 791-03).

Bag sold separately for connection to other processing sets.

Tubing is RF or heat sealable.

*BioArchive is a registered trademark of ThermoGenesis Corporation.

Application

For the long-term storage of 25 mL cryopreserved concentrated blood components. 

Advanced Bag Designs Meet Rigorous Industry Standards

Cord blood stem cells have been effectively used in the treatment of more than 70 malignant and non-malignant diseases, including sickle cell, leukemia, non-Hodgkins lymphoma, other forms of cancer, life-threatening anemias, and autoimmune diseases. As a key supplier to the cord blood banking industry, Pall provides a full range of bag sets that are used to prepare the cord blood stem cells for treatment.

Pall's collection and processing sets are manufactured to cGMP using validated manufacturing processes that ensure safe, consistent and reliable product performance. Each bag is 100% inspected prior to release and is fully traceable by lot number. Pall's bag sets are uniquely designed to facilitate closed system processing of cord blood stem cells by the volume reduction method developed at the New York Blood Center.¹ Volume reduction maximizes limited storage space while closed system processing minimizes sample loss and reduces the risk of contamination during handling. This method results in a high quality sample available for transplantation. SOP's referencing Pall bag sets are available at the EMMES website: https://web.emmes.com/study/cord/sop.htm¹

Assessment of stem cell content and viability after long-term storage is a critical step prior to a successful transplantation. International standards recommend storing a cell sample attached to a unit of cord blood for quality control testing. Pall's freezing bag includes sufficient tubing for the preparation of segments, enabling a sample aliquot to be cryopreserved with the final product. Using a tube segment for quality control testing prior to transplantation reduces the risk of contamination during the thawing process and provides critical information needed to predict treatment success.

For disease treatments or patient populations that require a higher cell dose to be transplanted, Pall's advanced freezing bag design divides the sample into two compartments, facilitating transfusion of 80% of the stem cells while retaining 20% of the stem cells for ex vivo cell expansion. Scientific advances in our ability to amplify stem cells will greatly expand the applications for hematopoietic stem cells from cord blood.

1. Rubinstein, P.; Dobrila, L.; Rosenfield, R.E.; Adamson, J.W.; Migliaccio, G.; Migliaccio, A.R.;Taylor, P.E.; Stevens, C.E. Processing and Cryopreservation of Placental/Umbilical Cord Blood for Unrelated Bone Marrow Reconstitution. Proc Natl Acad Sci USA. 1995, Oct 24;92(22):10119-22.

Product No.	791-05, 791-05U
Description	Freezing Bag
Fill Volume Range	Up to 25 mL
Port Configuration	In-line spike
Materials of Construction	Bags: Ethyl vinyl acetate, a copolymer of polyethylene; Tubing: Ethylene vinyl acetate
Bag Size(s)	8.84 cm length x 7.04 cm width x 0.74 cm depth (3.48 in. length x 2.77 in. width x 0.29 in. depth)
Sterilization	Gamma
Packaging	Four sterile bags packaged in a plastic pouch; 48/box
Shelf Life	3 years
Traceability	Lot number
Regulatory Status	FDA 510(k) cleared; CE marked

Facilitate each step in the collection, processing, freezing and transfusion process for cord blood stem cells to ensure a safe, reliable, robust process. See these other Pall products for the collection, processing and cryopreservation of blood and cellular components:

• Cord Blood Collection Set: For the collection of up to 150 mL of umbilical cord blood.
• Transfer/Freezing Bag Set: For processing and freezing 25 mL of cryopreserved, concentrated cord blood stem cells.
• Cord Blood Cell Wash/Infusion Bag Set: For the thaw/washing and subsequent infusion of previously frozen cord blood stem cells as developed by the New York Blood Center.
• Cord Blood Sterile Collection Bag: Safe and convenient cord blood collection for vaginal births and cesarean sections.

Product Code	Product Code (Europe)	Description	Packaging
791-05	791-05U	Freezing Bag	48 units/case

To Order, Contact:

Pall Medical

Tel: 877.367.7255
Fax: 888.556.7337
pall@rxcrossroads.com

Pall Europe Ltd

Europa House, Havant Street
Portsmouth, PO1 3PD England
Tel: +44 (0)23 9230 3452
Fax: +44 (0)23 9230 3324
Biosvc@Pall.com

Pall Canada

2535 De Miniac
St-Laurent, Quebec H45 1E5
Tel: +1 514.332.7255
Toll-free in Canada: 800.465.8555
Fax: +1 514.332.0996

Pall's cord blood processing products are not available in Asia or Latin America. For cord blood processing products in Asia and Latin America, please contact your local Thermogenesis representative.

Access our complete list of Pall offices worldwide.