Benchtop Tangential Flow Filtration Systems
Minim™ II Tangential Flow Filtration System
The 1 L reservoir with sealed lid can pull in additional product as a vacuum is developed as filtrate is removed from the system. This feature also allows continuous diafiltration to easily be performed. The Minim II System is an ideal development tool for running TFF trials with very small sample volumes, since it allows users to accurately scale-up process conditions and maximize yields. Use of easy-fit customized single-use tubing kits and a color-coded insert tray, sensors and connectors, facilitate perfect alignment for simplified system set-up and installation of system components. System hold-up and working volumes are minimized. Risk of cross-contamination from tubing is eliminated. An RS232 port allows operating parameters to be exported to an Excel* spreadsheet for easy data management.
Centramate™ 500 S Tangential Flow Filtration System
The Centramate 500 S benchtop tangential flow filtration system provides research and development labs with a compact TFF unit for process development in ultrafiltration (UF) and microfiltration (MF) applications. Use of a positive displacement diaphragm pump provides pressure independent flow, ensuring critical parameters do not vary during concentration. The four-piston diaphragm pump delivers constant flow even as the system pressure increases. Direct flow measurement with the magnetic inductive flowmeter means accurate, safe and simple operation is achieved.
A graduated 5 L glass vessel provides full visibility and indication of fluid level during operation, so volumes can be closely controlled. Designed with an ultra-compact flow path, the Centramate 500 S system allows users to operate at volumes as low as 170 mL (when using a single Centramate membrane cassette), enabling high concentration factors to be achieved while minimizing operating volumes. Development, time, risk and process volumes are all minimized.
The sanitary, self-venting, fully-drainable design meets the demands of cGMP environments, with full traceability of process-wetted materials. A completely drainable flow path maximizes product yield, and improves cleaning efficiency. Designed through experience, the Centramate 500 S TFF system meets the requirements for cGMP equipment with a comprehensive qualification and documentation package, calibrated process instrumentation and hygienic design. Data from the process instrumentation can be exported to a PC or laptop computer via the USB port on the Centramate 500 S system.