The acoustic wave separation (AWS), a disruptive technology from FloDesign Sonics (FDS) for cell culture clarification for both fed-batch and perfusion applications, enables very-high-efficiency continuous removal of the cells in a closed system without centrifugation. This thereby streamlines a challenging step in the biologics manufacturing process within a small operating footprint. The technology complements Pall's industry-leading STAX™ depth filtration products to enable continuous clarification of cell culture, enabling integration of the bioreactor with downstream processing.
The AWS technology works by applying acoustic forces across a flow channel to generate a three-dimensional standing wave. When a cell culture passes through the flow channel, the cells are trapped at the nodes of the acoustic waves and then aggregate, culminating in their precipitation from suspension as their buoyancy decreases. Important features are no temperature increase, no damage to cells or proteins, and the process works in a robust manner at high yields.
The integration of the AWS technology expands the portfolio of continuous bioprocessing and single-use products offered by Pall.
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