What's Next? Bioprocessing Products in Development

Pall's research and development teams are continually working to find more efficient, effective ways to solve your application challenges. This is one of the cornerstones of Pall's service to our customers. Check back regularly for news of future product developments.

Stax™ Depth Filters with Hyperion Flow Technology

Developed for direct mammalian cell harvest, this revolutionary new filter in Pall’s Stax™ capsule format removes cells and cellular debris effectively and efficiently. The patented Hyperion flow technology provides high capacity and significantly-reduced filter area. Utilizing Hyperion depth filtration enables a consistent single-use process for process volumes up to 2000 liters. With no intermediate centrifugation step or addition of flocculation media necessary, the entire process is simplified, reducing capital investment, costs of maintenance and space requirements. The Stax depth filter with Hyperion technology represents a major new innovation in cell removal technology.

If you would like any further information, or are interested in taking part in trials with your process solution in development, please contact hyperion@pall.com.

BioSMB® System
Pall's BioSMB platform is the first disposable flow path, continuous multi-column chromatography solution. Unique to biopharmaceuticals, the system is designed to boost productivity and optimize the use of chromatography sorbents.
  • Ideal for bind and elute chromatography
  • Reduces buffer tank requirements, even for complex product expression systems
  • Integrated single-use valve array easily services up to 16 columns/devices without complexity
  • Column configuration determined by total process volume rather than by product mass

Reducing space requirements and costs, the BioSMB system delivers a scaleable, flexible and single-use path to multi-column applications, and peerless productivity per unit area of manufacturing space.

If you would like any further information, or have an immediate application for this new system, please contact biosmb@pall.com.
Acoustic Wave Separation (AWS)

The acoustic wave separation (AWS), a disruptive technology from FloDesign Sonics (FDS) for cell culture clarification for both fed-batch and perfusion applications, enables very-high-efficiency continuous removal of the cells in a closed system without centrifugation. This thereby streamlines a challenging step in the biologics manufacturing process within a small operating footprint. The technology complements Pall's industry-leading STAX™ depth filtration products to enable continuous clarification of cell culture, enabling integration of the bioreactor with downstream processing.

The AWS technology works by applying acoustic forces across a flow channel to generate a three-dimensional standing wave. When a cell culture passes through the flow channel, the cells are trapped at the nodes of the acoustic waves and then aggregate, culminating in their precipitation from suspension as their buoyancy decreases. Important features are no temperature increase, no damage to cells or proteins, and the process works in a robust manner at high yields.

The integration of the AWS technology expands the portfolio of continuous bioprocessing and single-use products offered by Pall.

If you would like any further information, or have an immediate application for this new technology, please contact aws@pall.com.

1000 L Single-Use Bioreactor for Cell Culture Technology

Pall Life Sciences will shortly be launching the Allegro™ STR 1000 single-use bioreactor, a geometrical scale-up from the Allegro STR 200 single-use bioreactor, designed for working volumes from 300 to 1000 L.
The unique design of this system resolves the challenges that are generally associated with single-use bioreactors while embracing all the flexibility that single-use systems offer. The cubical design allows for the most effective use of the system footprint and acts as a natural baffle to improve mixing. A bottom driven impeller covers a large power input range to increase the design space. Extensive computational fluid dynamics and test data is available to assist with scaling.

Pall has optimized the packaging and the installation procedures to ensure easy installation and minimal risk of damage to the biocontainer. The software guides the user through the biocontainer installation steps, assuring a complete, quick and safe installation.

If you would like any further information, or have an immediate application for this new system, please contact bioreactors@pall.com.

For information on the characterization and performance of the Allegro™ STR 1000 single-use stirred tank bioreactor system please see the attached poster presented at ESACT 2015.
  Characterization and Performance of the Allegro™ STR 1000 Single-Use Stirred Tank Bioreactor System