Chromatography Columns for Process Development and Optimization

Pall offers a comprehensive line of chromatography columns for lab to process scale including:

PRC 1 mL and 5 mL
Prepacked Chromatography Columns

  • Convenient, ready-to-use, prepacked columns  
  • Direct connection to commonly-used laboratory chromatography systems
  • High packing efficiency

PRC 1 mL and 5 mL prepacked chromatography columnsPRC 1 mL and 5 mL prepacked columns are available in chemistries for mixed mode, ion exchange and affinity chromatography. Rapid screening and condition optimization in the 1 mL PRC column enables rapid selection of the appropriate chemistry. Once the chemistry is selected on a 1 mL PRC column, the conditions of use can be optimized in a 5 mL PRC column in doubling the height. Two or more columns can be connected in series to increase the column height and more closely model real conditions in pilot scale or for scale down applications. Choose:


Acrosep™ 1 mL Pre-Packed Chromatography Columns are also available to simplify protein purification and fractionation for biomarker discovery, proteomics research, and drug development in laboratory applications.

♦KANEKA KanCapA is a trademark of Kaneka Corp.

Resolute FM Chromatography Columns for Pilot or Production Use

Resolute FM Chromatography Columns for Pilot ScaleResolute FM columns are ideal for chromatographic purification from process development through to manufacturing scale with a wide range of commonly used media. These glass and acrylic columns for development and manufacturing applications, are robust and incorporate new features to improve the outcome of column packing events. The industry accepted constant compression seal design used in the successful Resolute large scale range is also incorporated in the FM series.

Features and Benefits

  • Sanitary design
  • Tilting mechanism for air removal
  • Ability to raise adjuster eliminates manual handling issues
  • Flexible unpacking from top or bottom of the column
  • Acrylic option available for glass sensitive proteins

Resolute DM, DP, and DAP Chromatography Columns for Production

  • Optimal process chromatography at manufacturing scale  from 280 mm to 2000 mm diameter
  • Reduced cost of ownership by minimizing buffer usage and labor
  • Reliable, reproducible, scalable performance

Resolute Chromatography ColumnResolute Chromatography Columns are ideally suited for process purification in the biopharmaceutical industry. Three-position nozzle valves provide all column functions required for packing, unpacking and running of the column in a closed system. Resolute columns provide excellent improved column performance, cleanability and true linear scalability combined with reproducible column packing methods for today’s high performance sorbents.

The packing process is supported by a Resolute Slurry Packing System which, combined with the Dynamic Axial Packing (DAP) hydraulic option on Resolute columns, offers a complete flexible, long-term solution to scale up process chromatographic purification from development to manufacturing.

Integrated systems for scalable packing and unpacking of process chromatography columns. Resolute™ slurry packing systems (SPS) are optimized for use with Resolute chromatography columns. With the flexibility of four systems in the series, column packing and unpacking can be optimized for one or multiple columns up to 2000 mm diameter.

The combined features of Resolute columns provide the most cost-effective technology for performing chromatographic purification to enhance your process economics.

  • Reproducible packed bed performance without repacking events
  • Reduced downtime with fast access for simple seal and bed support replacement
  • Efficient distribution system reduces Clean-In-Place (CIP) chemical and buffer consumption

Based on performance by design, Resolute columns will improve operating costs through reduced buffer usage and manpower while providing a technology that is flexible in order to meet your process needs for the foreseeable future, even with the most challenging sorbents.