Clarification and Prefiltration
In the biopharmaceutical marketplace where the requirement for high quality and cost-effective filtration is extensive, Pall® clarification and prefilters serve an important role in the removal of undesirable material from process streams and by protecting comparatively higher priced final filters, increasing their service life.Clarification filters remove contaminants from a fluid stream primarily by direct interception and sieving, where the unwanted particles are caught in or on the surface of the filter medium respectively. In addition, some liquid filters' removal capabilities can be achieved or enhanced by charge effects in which case they may retain undesirable species by adsorption.
Types of FiltrationThere are two classic types of direct flow clarification:
Filter FunctionsA distinction between these filters is important because the two types often serve different functions.
bioburden, remove particulate contamination and clarify solutions prior to further downstream processing. These products are optimized for best performance in the aforementioned applications, and offer excellent value when compared to other filter devices in the marketplace. Many of these products are fully scalable (from laboratory to manufacturing operations) and are available in single-use format.
Pall UpScaleSM Program - Clarification and PrefiltrationPall is well-equipped to support processes as they are scaled up. Different size cartridges and capsules for each specific Pall® prefilter grades contain identical materials of construction. This feature ensures that scale-up and scale-down studies yield relevant information with minimum requalification. The availability of a variety of capsules for small-scale operations is beneficial, particularly for new product development.
In a new product development, capital investment can be a concern since not all new biopharmaceutical products become commercialized, so single-use capsules make it possible to produce new products during the early development stages, without a large initial outlay.
Clarification products in Pall’s UpScaleSM range incorporate the following filter media:
- Nylon 66
- PTFE (polytetrafluoroethylene)
- Resin-bonded glass fiber
- Cellulose-based depth media
- Reduced assembly costs
- Reduced cleaning costs
- Reduced cleaning validation
- Reduced costs for capital equipment - capsule filters have a typical installation cost that is 80% lower than a similar sized stainless steel housing system
- Reduced risk of lost production time due to simple procedures
- Hazardous liquids can be contained during processing with minimal risk of operator exposure