Pall's UpScale Program

Pall recognizes that your finished products are often the results of applying painstaking research to a series of complex manufacturing steps. In various stages of the manufacturing process, direct flow filters, tangential flow filters and chromatography units are used to ensure the quality and safety of all your fluids. Pall offers a broad range of separation and purification products and technologies designed to meet the most stringent requirements of clarification, sterility, purity and safety.

Typical Applications Using Pall Products Include:

  • Aseptic Processing
  • Biologicals 
  • Bioprocessing/Fermentation
  • Downstream processing

Widest Selection of Separation Technology

Direct Flow Filtration

Pall® filters are recommended for applications that require high flow-rates and flexibility in optimal filter medium selection. There are many configurations of Pall® filters available: from high-capacity, high-efficiency depth filters to sterilizing-grade and fine membrane filters that can be sized to meet your needs from laboratory to pilot to the largest production scales.

Separation Systems for Bioprocessing

Pall offers the best solutions for optimizing applications, including a large range of proprietary tangential flow filtration cassettes and hollow fibers. These advanced technologies reduce maintenance and operating costs and optimize performance. All systems are available for feasibility and scale-up testing from laboratory and pilot to the largest production scales.

Upscale Toolbox
Direct Flow Filtration
Tangential Flow Filtration

Purification Systems for Bioprocessing

In addition to a wide range of columns and sorbents, Pall has developed innovative membrane chromatography solutions that will allow you to purify biomolecules or remove contaminants at the molecular level using chromatography techniques. All units are available from laboratory and pilot scales to the largest production scale to accommodate the volumes and processes found in the biopharmaceutical industry. Sorbents, which can be integrated into fully-automated systems, are available for small-scale process development to full-scale manufacturing.

Single-use Systems For Upstream and Downstream Processing

The fully-automated Allegro™ MVP single-use system from Pall Life Sciences is suitable for a wide range of upstream and downstream bioprocessing activities. Applications include: sterile filtration, bioburden reduction, depth filtration, virus filtration/inactivation, media & buffer preparation, membrane chromatography, pH adjustment and final formulation & filling. More information

Get Biopharmaceutical Products to Market Faster

The UpScaleSM program can simplify scale-up to save you time and money. It will allow you to get products to market faster by providing products with the same media and consistent materials of construction for all phases of development, from Research and Development to pilot, and ultimately full production. All of our separation products are designed for use in pharmaceutical applications and contain materials of construction that are fully compliant with the highest industry standards. These materials contribute to the safety and security that you demand for your products, whether they are used for clinical trials, or whether they are already fully licensed.

Many of our products are available in single-use formats that reduce the need for cleaning and cleaning validation. Pall can assemble them into complex single-use systems to provide you with extra tools to expedite the validation of your entire process and accelerate time to market.