The Most Versatile Disposable Depth Filter Platform
Stax capsules, utilizing Seitz® high performance depth filter media and the patented Supradisc™ II module design, are ideally suited for demanding prefiltration and clarification biopharmaceutical applications. This ready-to-use platform is an ideal tool to streamline your process filtration applications. Stax disposable depth filter capsules increase process efficiencies and address the needs for simplicity, safety, speed, and intuitive operation. Optimized with a small foot print design, the Stax platform makes for an easy to handle and operate process step.
Scalable in size and performance to meet lab, pilot and process needs, Pall’s Stax disposable capsules enable greater flexibility and ease of use than traditional depth filter technology. With three interchangeable capsule sizes ranging from 0.25 m2 to 2.0 m2 (2.70 ft2 to 21.5 ft2). Stax capsules permit incremental increases in process fluid volume and filter area through the use of this modular design.
Simple, Intuitive Operation
Placed into one of three different sized chassis, Pall’s single use Stax capsules eliminate the use of stainless steel housings which require costly cleaning and cleaning validation. Stax system chassis are designed for assembly and use by a single operator and provide a logically conceived disposable platform in which the operator can load, operate and unload in an ergonomically designed vertical orientation. The ability to operate with two different media grades in one chassis (serial filtration) further improves the flexibility and economy of operating the Stax platform. With simple, straight forward and familiar features, the Stax platform eliminates the risk of error or mishap and enables greater process success. Integrating Pall’s Allegro™ platforms into a comprehensive single-use system will further maximize the overall benefits of implementing a single-use strategy and the Stax platform.
Low hold-up volume
Greater product recovery and lower post use rinse volume requirements than traditional modules and housings. Post use blow down in forward or reverse flow direction are possible.
Seamless linear scalability
Greater flexibility and assurance of process success from <1L to 20,000+ L Scalable through Pall’s entire line of scale-up devices (Supracap™ 50 and Supracap 100 capsules) as well as traditional Supradisc I and Supradisc II modules. Provides assurance of meeting process design and requirements.
The Stax capsules are based upon the outstanding design of Pall’s Supradisc II modules, which provides benefits in process stability due to their high mechanical robustness.
Easier to use and manipulate while eliminating operator safety issues.
Eliminates need for cleaning and cleaning validation.
Reduces operator exposure to potential biohazards.
Reduces operator training and increases time to acceptance.
Enables use in close proximity to other equipment and reduces cost to install.
Benefiting from Pall’s Supradisc II mechanically robust module design, the Stax capsules provide stable filtration results batch to batch. Through the use of interlocking and welded dual drainage plates, this robust module design is able to provide the structural integrity necessary for:
Unobstructed process flow
Consistent filtration results
Minimized risk to filter media ruptures due toreverse pressure
Minimized risk of damage due to shipping and handling
The Stax platform has been designed to accommodate nearly all processing options. Whether you want to process:
Bottom in/bottom out
Simply using Pall’s uniquely designed manifold kits provides complete flexibility in your process design. Appropriate for use in primary and secondary filtration steps, as well as post-precipitation clarification, in applications such as:
Mammalian cell cultures
E.coli lysates and refolds
Blood plasma proteins and serum
The Pall Stax capsules are available in a wide array of advanced pharmaceutical-grade Seitz depth filter media. Supported through comprehensive validation guides, Seitz depth filter media meets the highest pharmaceutical standards for:
Low extactable content
Low endotoxin content
Providing Linear and Seamless Scalability
Enabling technologies such as the Pall Stax system must be supported with complementary products and devices that provide seamless linear scalability in filtration performance from bench to process. For this reason Pall has developed a complete line of scaled-down disposable capsules utilizing the same design principle, flow path, and filter media as the Stax capsules.
Scalability - Depth Filter Sheet Media Format
Scalability - Effective Filter Area
Supracap 60 Capsules (<1 to 3 liters)
26 cm² (0.028 ft²) of EFA*
Supracap 100 Capsules (3 to 100+ liters)
5 in. capsules
0.05 m² (0.54 ft²) SL(1) EFA 0.025 m² (0.27 ft²) DL(2) EFA
10 in. capsules
0.1 m² (1.08 ft²) SL EFA 0.05 m² (0.54 ft²) DL EFA
20 in. capsules
0.2 m² (2.15 ft²) SL EFA 0.1 m² (1.08 ft²) DL EFA
30 in. capsules
0.3 m² (3.23 ft²) SL EFA 0.15 m² (1.61 ft²) DL EFA
Stax Capsules (50 to 20.000+ liters)
0.5 m² (5.38 ft²) SL EFA 0.25 m² (2.70 ft²) DL EFA
1.0 m² (10.8 ft²) SL EFA 0.5 m² (5.38 ft²) DL EFA
2.0 m² (21.5 ft²) SL EFA 1.0 m² (10.8 ft²) DL EFA
*EFA = Effective filtration area
(1) SL = Single layer Seitz depth filter media such as P-series and BIO-series (2) DL = Double layer Seitz depth filter media such as HP-series
Seitz depth filter media available in Stax capsules:
Seitz P-series depth filter sheets were specifically developed for the strict requirements in biotechnological and pharmaceutical industries. Manufactured with stringent in-process control methods assures consistent filtration quality, a very high purity of filter medium, and alignment with the requirements of the pharmaceutical industry. For further information, please reference Pall data sheet USD 2205 or validation guide USTR 2366.
Seitz HP-series depth filter sheets are comprised of two distinct layers of Seitz P-series depth filter sheets; a coarser layer upstream followed by a finer layer downstream. These performance-enhanced depth filter sheets have been designed for use in low viability, high solids containing applications. As small shifts in process conditions can cause dramatic differences in filtration requirements, the flexibility of combining any combination of P-series media in an HP format allows for improved process optimization. For further information, please reference Pall data sheet USD 2335 or validation guide USTR 2404.
Seitz Bio-series depth filter sheets are specially developed from highly purified natural and modified cellulose fibers and contain no inorganic materials such as diatomaceous earth (DE), perlite or glass fibers. The lack of these inorganic substances significantly reduces the levels of ash and heavy metal extractables. For further information please reference Pall data sheet USD 2201.
Nominal Retention Rating of Seitz P-series, HP-series and Bio-series Depth Filter Sheet Media