Small Virus-Retentive Filters

Pegasus™ SV4 Virus Removal Filters

With the ever-present risk of virus contamination in biologic products, potential sources of virus contamination of biotechnology products include viruses associated with cell lines (endogenous viruses), or viruses introduced into the cell line or product from culture medium or during the production process (adventitious viruses). Viruses could also potentially be present in donations for plasma derivatives. Pegasus SV4 Virus Removal Filters are direct flow filters combining robust, high viral clearance of parvovirus and larger viruses with high throughput capacity and demonstrating constant, stable flow-rates in both dilute and complex/concentrated biological fluids. Such consistent, constant flow rates and outstanding throughput performance allows a very high degree of process control.

Laboratory and Viral Clearance Validation

Pall Minidisc Virus Removal Capsules
with Pegasus SV4 membrane

Purpose-designed for small-scale membrane qualification studies such as virus, bacteriophage or prion (TSE agent) clearance, as well as membrane flow rate, capacity and protein transmission studies.
 
 












Scale-Up Studies

Mini Kleenpak™ Capsule Filterability Tool with Pegasus SV4 membrane
Designed for quick and efficient filter sizing studies using small fluid volumes either following, or instead of bench scale flat disc trials. Studies performed using this device predict filtration area requirements of Pegasus SV4 membrane in larger, AB-style filter cartridges or Kleenpak Nova filter capsules.
 

Full-Scale Virus Filtration

Pegasus SV4 Virus Removal Filter Cartridges
Integrity testable, autoclavable or steamable direct flow filter cartridges for full-scale manufacturing, designed to remove the smallest viruses from protein solutions. Pegasus SV4 Virus Removal Filter Cartridges are suitable for inclusion into available fully-automated systems.
 

Single-Use Virus Filters

Kleenpak Nova Filter Capsules with Pegasus SV4 Virus Removal Membrane
Single-use, integrity testable, autoclavable direct flow virus filters for full-scale manufacturing, designed to remove the smallest viruses from protein solutions. Kleenpak Nova Filter Capsules with Pegasus SV4 Virus Removal Membrane are suitable for inclusion into fully-automated Allegro™ MVP virus filter systems.
 

Also Available

Ultipor® VF Grade UDV20 Virus Removal Filters

Direct flow filters for size-exclusion removal of smallest viruses. Ultipor VF grade UDV20 filter cartridges are characterized by robust and stable high performance, in a wide range of process conditions.

Laboratory and Viral Clearance Validation

Pall Minidisc Virus Removal Capsules with Ultipor® VF Grade DV20 Virus Removal Filter Membrane
For small-scale membrane qualification studies such as virus, bacteriophage or prion (TSE agent) clearance, as well as membrane flow-rate, capacity and protein transmission studies, also suitable for scale-up studies.

Scale-up and Small-Scale Virus Filtration

Novasip™ DV20 Virus Removal Filter Capsules
Single-use, integrity testable, autoclavable or steamable assemblies, designed to remove smallest viruses from protein solutions, also suitable for scale-up studies and small scale production.

Full-Scale Virus Filtration

Ultipor® VF Grade UDV20 Virus Removal Filter Cartridges
Integrity testable, autoclavable or steamable direct flow filter cartridges for full-scale manufacturing, designed to remove the smallest viruses from protein solutions.

Kleenpak Nova Filter Capsules with Ultipor Grade DV20 Virus Removal Membrane
Single-use, integrity testable, autoclavable direct flow virus filters for full-scale manufacturing, designed to remove the smallest viruses from protein solutions.