Acrodisc® PSF Syringe Filters Expedite Automated Sample Processing

Ideal for HPLC and UHPLC Automated Sample Processing and Sample Clarification

  • Accurate pore size rating – Acrodisc PSF syringe filters are more retentive than standard 25 mm devices and are available with single-layer membranes or multilayer glass fiber prefilters.
  • Superior HPLC column protection – Better retention efficiency helps extend column life as much as 46 times.
  • Quick and easy filtration – GxF multi-layer prefilter provides two to four times the throughput of standard glass fiber prefilter devices.
  • Safety feature – Filter housing has been designed to withstand high operating pressures to avoid filter burst during use.
  • Versatile – Available with GHP hydrophilic polypropylene membrane for maximum chemical compatibility, fast flow rates, low protein binding, and low levels of UVabsorbing extractables.
  • Automation certified – Designed to be fully compatible and reliable for use with the SOTAXu and Zymarku automated test systems.


Automation Certification

Pall's Acrodisc PSF syringe filters are the only syringe filters to receive SOTAX and Zymark Automation Certified guarantees. This certification is granted to syringe filters that meet the stringent requirements for automated dispensing, robotic handling, and fit and operation in the SOTAX dissolution systems. Acrodisc PSF syringe filters are fully compatible for use with SOTAX and Zymark automated workstations and facilitate smooth operation and worry-free performance 24 hours a day.

HPLC Certified

Pall Life Sciences certifies Acrodisc PSF syringe filters with PTFE, nylon, PVDF, and GHP membrane to be low in UV absorbing extractables. They have been tested for compatibility with common HPLC solvents (water, acetonitrile, and methanol) using established HPLC procedures. Filtrate from a statistical sampling of Acrodisc PSF syringe filters was collected and run under gradient mobile phase conditions at three common wavelengths. The chromatograms of the solvent blanks and samples were compared. Samples from each production lot were also compared to a standard to determine if any extraneous peaks were present.
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Ion Chromatography Certified

Pall Life Sciences certifies that the following Ion Chromatography (IC) Acrodisc PSF syringe filters have been tested using a highly sensitive ion chromatography technique: PN AP-4585, AP-4587, and AP-4785.

To monitor inorganic extractables, samples from each lot are tested. Actual background levels of filter extractables are typically less than 20 ppb for chloride, 6 ppb for nitrate, 1 ppb for phosphate, and 10 ppb for sulfate.


Retention Efficiency

The retention efficiency of the Acrodisc PSF filter can directly increase the life of your HPLC column. More retentive filters will also remove smaller non-dissolved particles that may rest on the head of your HPLC column and affect your analytical results as they dissolve during an analysis. The graph below demonstrates that the life of an HPLC column can be extended up to 46 times by filter samples prior to injection. For the complete study, see PN 33312, Syringe Filter Efficiency and Effect of Filtration on HPLC Column Life Scientific and Technical Report.

Figure 1
Effects of Filters on HPLC Column Life


The GxF Acrodisc PSF syringe filter has a serial glass fiber prefilter to allow for maximum throughput and faster flow rates than standard glass fiber prefilter devices. The multi-layered prefilter traps particulate rated from > 40 to 1 µm.

Figure 2
The Acrodisc PSF Syringe Filter

Figure 3
Comparison of Syringe Filters

A significant improvement in the amount of three difficult-to-filter solutions is seen with the addition of Pall Life Sciences prefilters. Vitamins (3 tablets/liter), Benadryl* (12 tablets/liter) and orange juice (from concentrate) solutions were filtered at 5 psi at room temperature. Throughputs were measured until flow rates dropped below 1 drop/sec. All devices have a 0.45 µm membrane and graded density glass fiber prefilter. Error bars indicate standard deviation (n = 10).


Acrodisc PSF syringe filters are designed specifically to meet the exacting requirements of automation systems and to demonstrate critical criteria including smooth filter-to-filter release, consistent turret advancement, exceptional housing strength, and a strict outside filter geometry to ensure proper alignment and consistent operation.

Pall’s Acrodisc PSF syringe filters are manufactured to the critical tolerances necessary to ensure accurate and reliable performance. These filters have been engineered to specific dimensions to provide uniform housing and optimized inlet and outlet designs. Stringent adherence to such critical dimensions is vital in ensuring consistent filter delivery, positioning, and operation of each and every filter that passes through automated workstations.

For a copy of the automation certification report, see Certification of Pall Acrodisc PSF Syringe Filters for Use with Zymark* Workstations.

Exceptional Housing Strength

Filter flex or squeeze occurs when the workstation’s filter holder compresses soft or weak filter housings. This squeezing effect reduces effective filtration area and can result in early clogging of the membrane. This clogging can potentially result in one of three situations:
  1. A leak between the filter and the workstation’s filter holder seal.
  2. An increase in back pressure resulting in operation shutdown.
  3. The filter housing bursts.

Filter squeeze is not a problem for the Acrodisc PSF syringe filter. The specially designed support ribbing, thick walls, and proprietary housing weld ensure a robust seal and a filter housing that can withstand excessive force both internally and externally.

Figure 4
Filter Squeeze, Competitive Device vs. Acrodisc PSF Syringe Filter

Smooth Filter-to-Filter Release

Filter sticking occurs when the filters do not easily release from one another, from the workstation’s filter holder luer at the filtration station, or from the filter weight. (The filter weight seats the filter in the dispenser hole.) If the filter does not release from the weight or the next filter in the dispensing area, the turret will jam. The workstation’s sensor will indicate that a filter has not advanced into place and the system will “error” or shutdown.

The Acrodisc PSF syringe filter has been designed so the filters cannot be forced too tightly together or to the automation components, making a smooth release while still meeting ANSI/ISO filter luer standards.

Figure 5
Smooth Filter-to-Filter Release

Strict “Outside Filter Geometry”

Consistent filter dimensions are critical for smooth operation in automated equipment. The Acrodisc PSF syringe filter has strict dimensional specifications in height and width to ensure proper alignment and filter luer-to-instrument placement.

Figure 6
Consistent Filter Dimensions

Consistent Turret Advancement

As the turret or carousel in systems such as the Zymark TPW3, SOTAX CTS, and Zymark APW3 systems turns to dispense a filter, the bottom filter on a stack drops into the filter separator area and a wedge mechanism separates the filter from the filter stack. If the filters are pressed too tightly together, the turret does not exert enough force to pull the filters apart. Occasionally when this happens, the filter stack will “jump” in the dispenser as the turret attempts to turn and the square-top shoulder on a syringe filter will snag on the edge of the separator wedge. When the turret freezes and a filter is not dispensed, the system errors and shuts down.

The Acrodisc PSF syringe filter’s quick-releasing filter luers separate easily. The slightly rounded upper shoulder on the device allows the filter to consistently slide under the wedge for trouble-free separation from the filter stack and smooth filter advancement along the workstation track.

Figure 7
Consistent Turret Advancement


Chemical Compatibility Guide

Solvent GxF/GHP, GxF/PTFE, GxF/Glass, GHP, PTFE HT Tuffryn Versapor GxF/Nylon, Nylon IC, Supor (PES) GxF/PVDF, PVDF
Acetone R NR NR R** NR* NR
Acetonitrile R NR NR R** R R
Acetic acid, glacial R R NR NR* R R
n-Butanol R R R R* R R
Chloroform R NR NR R* NR R
Dimethyl formamide R NR NR R** NR NR
Dimethyl sulfoxide R NR NR R** NR NR
Ethanol R R R R* R R
Ethyl acetate R NR R R** NR R
Ethyl ether R NR R R* R R
Freon TF R R* LR R
Hydrochloric acid (1N)          R R NR R R

Solvent GxF/GHP, GxF/PTFE, GxF/Glass, GHP, PTFE HT Tuffryn Versapor GxF/Nylon, Nylon IC, Supor (PES) GxF/PVDF, PVDF
Hexane, dry R R R R LR R
Methanol R LR R R* R R
Methylene chloride R NR NR R* NR R
Methyl ethyl ketone R NR NR NR** NR NR
N-Methyl pyrrolidone R R* NR R
Isopropanol R R R R* R R
Sodium hydroxide (3N) LR R R R R NR
Tetrahydrofuran R NR NR R* NR NR
Tetrahydrofuran/water (50/50) R R* R
Toluene R NR R R** R R
Water R R R R* R R

R = RESISTANT. No significant change was observed in flow rate or bubble point.
LR = LIMITED RESISTANCE. Moderate changes in physical properties of the membrane were observed.
NR = NOT RESISTANT. The membrane is basically unstable. In most cases, extensive shrinkage or swelling occurs.
  = Insufficient data
* = UV absorbance was set at 254 nm
** = UV absorbance was set at 365 nm


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