Chromatography - Vaccine Purification
Pall Mustang Q anion exchange membrane utilizes a microporous membrane with active Q chemistries linked directly to the membrane surface. By using three-dimensional structures with open (0.8 µm) pores, active chemistry groups are immediately available for binding. The membrane’s 8000Å convective pores are ideal for purifying large molecular weight targets such as plasmid DNA; and, dynamic binding capacity of up to 20 mg DNA/mL of membrane has been observed. As a result, where traditional process chromatography can require time-consuming experiments to determine optimal flow rates to maximize dynamic binding capacities, chromatography membranes operate at much higher volumetric throughputs (up to 40 bed volume/min) and with greater binding capacity as molecular weight increases.