Syringe Filter Selection Guide - Part 2 of 4

Consider the following when choosing the best filter for your analytical application:

Part 2: Filter Chemical Compatibility

Does the filter need to be resistant to bases, acids, or organic solvents? Chemical compatibility is a critical consideration when selecting the sample prep syringe filter or mobile phase disc filter for your application. The following broad guidelines can be used for basic information.
  • Aqueous Samples. Hydrophilic membranes, which have an affinity for water, are preferable when filtering aqueous samples. Use Pall filters with GHP, PES, Nylon, or PVDF membranes.
  • Gases and Aggressive Organic Solvents. Hydrophobic membranes repel water and are inert to aggressive organic solvents, making them ideal for gases and organic solvents. Choose Pall filters with PTFE membrane.
  • Aqueous and Organic-solvent Solutions. Different polymeric membranes have different chemical compatibilities. Based on the application and chemical compatibility, there may be one or several membrane and Acrodisc syringe filter possibilities. Generally, one filter type will not function for all applications due to limitations in hydrophobicity/hydrophilicity and chemical compatibility. However, Pall's patented hydrophilic polypropylene (GHP) membrane is a universal membrane for both aqueous and organic applications.
  • Exceptionally Low Extractable Levels. A filter is designed to increase accuracy by removing unwanted particles. However, the wrong filter can be a source of contaminants in the form of extractables that elute into the sample from the filter device. These undesired artifacts can jeopardize analytical results. Some extractable concerns include coelution, false quantitation, and extraneous peaks. Pall Life Sciences specifically selects the highest grade of materials and performs rigorous extraction methods on our membrane products to remove the occurrence of undesired artifacts.
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Analytical Sample Preparation Product Selection Guide
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  • HPLC Certified for Low Extractables. Pall Life Sciences HPLC certification ensures that analytical results will not be compromised by extractable filter materials. To verify low levels of UV-detectable extractables, samples of the HPLC Acrodisc syringe filter line are randomly taken and tested for compatibility with common HPLC olvents using standard HPLC conditions.
  • IC Certified for Low Levels of Inorganic Extractables. Pall certifies Ion Chromatography (IC) Acrodisc® syringe filters have been tested using a highly sensitive IC protocol to monitor inorganic extractables. For ion chromatography applications, only the IC Acrodisc (PES) syringe filter is certified for low levels of inorganic extractables. Actual background levels of filter extractables are typically less than 20 ppb for chloride, 6 ppb for nitrate, 1 ppb for phosphate, and 10 ppb for sulfate.
  • Low Sample Adsorption. Choose a low adsorbing filter such as the Acrodisc syringe filter with GHP membrane. GHP membrane is extremely low in biomolecule binding. Typical binding levels are far below 1%.
  • Color-coding for Easy Identification. All analytical sample prep Acrodisc syringe filters and their packaging have color-coded printing with membrane type and pore size on each filter:
    •  GHP
    •  Nylon
    •  PTFE
    •  Glass Fiber
    •  PVDF
    •  Polyethersulfone (PES)

Additional Information