The Allegro single-use platform provides a comprehensive range of disposable process solutions from upstream, through downstream to formulation and filling. We have developed a unique approach, keeping the same materials of construction to allow easy scale-up from lab scale to full cGMP commercial operation, with the capability to provide the same robustness, reliability and batch records that you require to produce your drugs. We can serve our customers globally with strong technical support and a very robust and reliable supply chain with our global manufacturing platform meeting all the necessary quality requirements. We pride ourselves on the strong quality, quality by design and ease-of-use attributes that we put in to all our Allegro single-use systems, thus allowing our end users to meet all the safety and regulatory requirements.Contact a Pall single-use specialist for more information
The evolution of the single-use market has developed from simple liquid filtration applications to progressively more complex process steps, across a range of upstream and downstream applications. As a result, our end users require the possibility to operate in single-use mode but with the level of reliability and robustness provided by fully automated process solutions.
The availability of single-use sensors (eg for pressure, flow, conductivity) allows designs of disposable flowpaths that incorporate these sensors to monitor key process parameters.
Automated systems for running complex single-use processes can deliver consistency in product quality, reduced labor costs and reduction of operator errors.Contact a Pall single-use specialist for more information
The Allegro SUTFF fully automated system offers robust and reliable manufacturing, providing a consistently high quality product. Fully disposable flowpaths offer choices of single-use sensors and connection to Cadence™ SUTFF modules.More information >>
The Allegro MVP fully automated system can be used in many different single-use processes involving direct flow filtration and pH adjustment. Provides reliable control of key process parameters, using fully disposable flowpaths.More information >>
Pall provides the broadest range of single-use mixers, covering all potential applications and requirements. Our magnetic drive technologies (Magnetic and LevMixer® units) represent the foundation of the largest installed base of mixing technology globally. With our automation expertise and complimentary technologies, such as the Pall powder bags and the Allegro™ MVP system, we can provide full automation around mixing applications with our standard systems, or customized solutions.More information >>
Allegro Jacketed totes include insulation on all 4 jacketed faces. With an internal Ra < 0.5 µm to maximize contact for efficient thermal transfer. They can be stacked to save floor space. The specially designed thermo channels provides very efficient heat transfer.More information >>
Pall now provides an extensive range of next generation single-use bioreactor systems designed for specific upstream applications , from R&D to full production, including:
-Allegro™ suspension bioreactors for Recombinant Protein manufacturing
-PadReactor® systems for optimized Microcarrier applications
-iCELLis® fixed-bed systems for Vaccine and Viral Vaccine manufacturing, and
-Xpansion® multi-plate bioreactors for Cell Therapy
Pall’s single-use bioreactors offer performance improvements, operational simplicity, and improved reliability for your critical upstream operations.More information >>
Pall is the market leader in sterile connection and disconnection technology. Coupling this with the Allegro single-use filling needles and ultra clean sterilizable packaging ,these technologies provide complete solutions for end users for final fill operations.
All of these technologies have been validated and qualified to the current regulatory standards in order to assure the highest level of quality assurance in these critical operations.Contact a Pall single-use specialist for more information
Kleenpak Presto sterile connectors are an easy-to-use genderless technology for the sterile connection of two fluid paths even in uncontrolled environments. Available in sizes ¼ in., ⅜ in., ½ in. and ⅝ in. hose barb and ½ in. sanitary connection.More information >>
Kleenpak sterile connectors are an easy to use, single-use technology for the connection of disposable systems and manifolds, even in an uncontrolled environment, while maintaining the sterile integrity of the connected systems. Available in 1⁄4 in to 1⁄2 in. connections.More information >>
Kleenpak II sterile connector is a robust, easy to use sterile connection technology for high volume sterile fluid transfer in single-use or hybrid systems.More information >>
Kleenpak sterile disconnectors provide an easy to use and secure method for the permanent sterile disconnection of flexible tubing assemblies even in an uncontrolled environment. It can be used in processes involving single-use systems as well as hybrid systems (single-use in combination with stainless steel equipment).More information >>
Allegro single-use filling needles are the ready to use disposable solution for final filling, eliminating cross contamination and costly cleaning validation. They come in sizes from 0.8 – 6 mm.More information >>
Pall produces a range of off-the-shelf sterilizable packaging materials for all your final fill components and ingredients. Our sterilizable packaging is also available in customized sizes and different shapes (such as bags, tubing, film, sheets, sleeves etc).More information >>
Pyrofree vials are ready-to-use glass vials, from 2 mL to 20 mL, facilitating the filling of sterile drug products. Small batches process is accelerated and improved thanks to these vials, packed under vacuum then sterilized and depyrogenated by a unique process.More information >>
The Allegro portfolio provides a comprehensive range of single-use systems and hardware designed for minimum operator interaction, robust fluid handling and product safety. Our Allegro biocontainer systems and hardware are designed to work together, using the same state-of-the-art, transparent, low extractables film from small scale up to the largest 3D biocontainer. 100% biocontainer leak testing at manufacture and self-filling provides unparalleled process safety in single-use fluid handling.Contact a Pall single-use specialist for more information
Allegro stainless steel totes provide extreme ease-of-use in installation and operation with full access doors and ‘easy-fill’ with no user manipulation required once filling is started. The sloped floor to outlet for minimizes fluid losses.
Available for production scale volumes from 100 L to 3,000 L
Allegro plastic totes provide a light weight, collapsible, corrosion resistant alternative to stainless steel totes. They can be stacked when open or collapsed to save floor space and are available in sizes 200 – 1000 L.More information >>
Allegro transportation totes allow the safe transport of fluid volumes up to 500 L. Tested in accordance with the International Safe Transit Association (ISTA) and the United Nations Economic Commission for Europe (UNECE) for road transport.More information >>
Allegro bioprocessing workstations are highly flexible and configurable trolley and tray combinations which can be adapted to meet multiple fluid handling application requirements throughout any process.More information >>
Allegro single-use systems are supported with extensive validation packages, including component validation, 100% biocontainer leak testing, generic extractables data and system joint testing compliance.
Standard systems are available in sizes from 50 mL to 3000 L
The Palltronic® Flowstar LGR test instrument enables point-of-use leak testing of single-use systems up to 200 L nominal volume and provides the ability to test filter integrity.More information >>
Pall offers a wide range of validation, process development and consultancy services tailored for your specific needs for single-use technologies and applications. Our global team of experts can assist you from scale up to commercialization of biopharmaceutical processes. With over 40 years’ experience our SLS global technical support group can be your partner in single-use process solution and optimization.Contact a Pall single-use specialist for more information
Pall Accelerator Development Services enable aggressive timelines with customized bioprocess support. Our experienced scientists and worldwide laboratories specialize in maximizing the benefits of Pall’s innovative single-use technologies. Services are targeted to project needs and include cell culture process development, on-site technical support, consultation services and tailored training courses.More information >>
Pall service contracts are not just for repair services. They help keep your bioreactor system in top condition, and provide you priority access to our global network of Technical Support, Field Applications and Field Service Engineers. We are dedicated to helping you succeed, and to providing rapid solutions to your problems.More information >>
Pall offers validation services covering areas including extractables and leachables, compatibility testing and sterilizing filter capsule validation, in line with the most recent best practises from both government and industry organizations.More information >>
Pall’s global technical support groups can provide assistance with scale up trials for filtration, TFF and a wide variety of single-use services design and optimization of systems, including for filter integrity testing.More information >>