 In today's economic environment, blood centers are looking for ways to enhance the services and product mix that they can offer to their hospital customers. Freezing pools of Cryoprecipitate AHF offers several benefits to their customers.
- Standardized dosing
- cGMP assurance
- Hospital labor and time savings
- Reduction in pooled cryo product loss
To assist our customers, Pall Medical has developed a pooling transfer bag set that is ideal for Cryoprecipitate AHF pooling – the Transfer Bag 400 mL Bag with Multileads. This pooling transfer bag set complements the objectives of Pall’s Leukotrap Synergy Platform by improving the supply, safety and savings of the products you produce. |
![]() |
 |
Download a PDF of product literature 
Improve Supply: Flexibility to increase product availability to meet your customers’ needs and help your facilities growth target.
- 6 manifold leads allow Blood Establishments to determine their own pool size.
- When the order is placed from the Trauma Center or Surgery Suite, Pall’s Transfer Bag offers a time saving, ready-available alternative to Cryoprecipitate AHF pooling on demand.
Increase Safety: Reliability to deliver high quality blood products.
- All tubing is compatible with standard sterile tubing connection devices.
- Set design allows for pre-storage pooling to be performed in a “closed system”.
Grow Savings: Profitability from streamlined processes and waste reduction.
- The 400 mL transfer bag can be packaged in standard FFP cartons, which can be easily stored in freezer units and distributed in shipping containers with minimal breakage.
- Provides an opportunity to expand product mix and services.
Transfer Bag with Multileads Features
- Spiked leads allow flexibility for open or closed system processing.
- 7 inch tubing manifold reduce product loss and maximize Cryoprecipitate AHF recovery.
- 6-to-1 tubing manifold connector reduces product loss.
- Temporary clamp located between the manifold and transfer bag helps to control the pooling process.
- 400 mL Transfer Bag is designed for storage in standard FFP containers.
- Interim ISBT128 & Codabar label on enhanced paper for improved adhesion of overlabels.
Best Practices for the Production of Cryoprecipitate
- To maximize the amount of plasma in 1st stage cryoprecipitate, the AABB recommends at least 200 mL (205g) cell-free plasma.
- Rapid freezing of 1st stage cryoprecipitate has been found to increase Factor VIII yield in Cryoprecipitate AHF; hence, use lower temperature freezer units for freezing in lieu of -18 °C freezer units.
- Thaw 1st stage cryoprecipitate to “slushy consistency”. Do not over-thaw.1 Consider thawing similar volume 1st stage cryoprecipitate to better control thaw rate.
- Chill centrifuge and centrifuge buckets and liners to 1-6 °C.
- Load chilled centrifuge buckets with two 1st stage cryoprecipitate units per bucket inside refrigerated walk-in or using insulated gloves. Immediately, place loaded centrifuge buckets in chilled centrifuge.
- Centrifuge at 1-6 °C using conditions to yield cell-free plasma.
- Centrifuge using brake settings parameters that are moderate-hard to preserve cryoprecipitate pellet.
- Remove spun 1st stage cryoprecipitate from the centrifuge and continue processing in batch sizes that allow the intermediate product to remain cold. Units should be handled gently. Consider using insulated gloves and/or placing on units on ice versus a room temperature countertop.
- Leave adequate volume on single cryoprecipitate to produce “Wet Cryo” of > 15 mL. When pooling, consider producing 20 to 25 mL single cryoprecipitate products and maintain target volume range.
Best Practices for the Production of Pooled Cryoprecipitate
- Load chilled centrifuge buckets with two 1st stage cryoprecipitate units per bucket inside refrigerated walk-in or using insulated gloves. Immediately, place loaded centrifuge buckets in chilled centrifuge.
- Determine ABO identical 1st stage cryoprecipitate units prior to thawing.
- Batch ABO identical 1st stage cryoprecipitate in processing steps.
- Determine 1st stage cryoprecipitate volumes prior to thawing.
- Batch similar volumes when thawing 1st stage cryoprecipitate units.
- Sterile connect as close as possible to 6-to-1 connector to maximize recovery.
- Pool single cryoprecipitate units simultaneously versus sequentially to reduce process time.
- If flushing/rinsing tubing and bags, use insulated gloves or only touch the outside of the bag.
- Use storage carton or bubble wrap final pooled product to reduce breakage.
- Part Number: 732-42M
- Description: Transfer Bag with Multileads (6)
- Packaging: 96 sets, bulk packaged (24 sets/inner box; 4 inner boxes per case)
Latex content: This product is free of natural rubber latex.
Contact your local Pall sales representative in order to obtain more information about the Transfer Bag 400 mL Bag with Multileads for your blood program.
SHARE
