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Establishing a platform for developing and manufacturing therapeutic proteins that ensures predictable productivity and product quality will eliminate bottlenecks in tech transfer.
In this case study, Celltheon demonstrates a workflow using the Celltheon SMART Technology Platform in combination with the Allegro™ STR bioreactor range. The time from cDNA to RCB was reduced to less than 4 months while ensuring scalability between 3L to 200L pilot scale, with a pre-defined upstream and downstream processing platform for monoclonal antibodies and difficult to express proteins.
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Case studies of Adeno-Associated Virus (AAV) and Lentivirus (LV) production using adherent and suspension cell culture