Lab-scale TFF systems

Rapid and efficient method for separation and purification of biomolecules

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Diagram showing how a lab TFF system works

Concentration, fractionation, and buffer exchange

Tangential flow filtration (TFF) is a rapid and efficient method for the separation and purification of biomolecules by utilizing ultrafiltration membranes. TFF can be used to concentrate and desalt sample solutions ranging from 10 mL to thousands of liters. It can be used to fractionate large from small biomolecules, harvest cell suspensions, and clarify cell lysates.

Lab TFF system photo

Laboratory-scale system

We offer a complete laboratory scale TFF system, the Minimate™ EVO TFF System (Pall™ Life Sciences products). The system features a plug-n-play design. Plug in a Minimate TFF capsule, add sample, and turn on the pump to start processing. The Minimate EVO TFF system includes all the hardware, tubing, and fittings needed to get your TFF process up and running quickly.

TFF system diafiltration setup

Flexible diafiltration

Diafiltration is a fast and efficient method for performing desalting, or buffer exchange of biological samples. The Minimate EVO TFF system allows users the flexibility to operate either continuous or discontinuous diafiltration, followed by sequential concentration in the same closed loop system. High concentration factors can be achieved, with sample volume reductions down to as little as 5 mL.