LCMS Sample Preparation - Analytical Quality Control

Reducing External Contaminants

Increased versitility and superior performance

The first LCMS certified filter with extremely low levels of extractables.

In analytical sample preparation, extraction and leaching of chemical compounds from filters are major concerns, particularly when using liquid chromatography mass spectrometry (LCMS) for analysis. LCMS has gained popularity due to its versatility and superior sensitivity for both qualitative and quantitative analyses. In LCMS instrumentation, one of the major foci of recent advancements is the improvement of method sensitivity that affords analysis at much lower limits of detection (< pg/mL). 


The emerging trend in LCMS enables analysis at low levels while the demand to reduce external contaminations, such as those coming from the filter, becomes more apparent. It is obvious that an underlying issue, when filtration is used for sample preparation, is the need to reduce the amount of extractables and leachables in the filter effluents that may ultimately jeopardize analytical results and data interpretation. 


The Acrodisc MS syringe filter was designed specifically to extend the lifespan of UHPLC columns used in Liquid Chromatography/Mass Spectrometry (LC/MS) analytical sample preparation without adding significant extractables and with minimal analyte adsorption. These filters are constructed with a water-wettable polytetrafluoroethylene (WWPTFE) membrane in high density polyethylene (HDPE) housings. The efficiency of the filters at removing particulates was examined using 0.05% polymer microsphere suspensions with an average diameter of 0.31 μm.