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IV Filtration in Infusion Therapy

Taking the lead in drug delivery and parenteral nutrition

Optimizing Infusion Therapy Since 1960

Get to Know Our State-of-the-Art Intravenous (IV) In-Line Filtration Systems

Intravenous drug infusions are a life-saving therapy. But unfortunately, these drugs may be infused in conjunction with inadvertent ambient air, bacteria, endotoxins and particles which can potentially put the patient’s health at risk.1–4


Where Our IV In-Line Filters Come Into Play


Experimental and clinical studies have proven that our IV in-line filtration devices can retain particles, air bubbles, microorganisms and associated endotoxins.5–7 Additionally, the implementation of IV in-line filters may improve patient outcomes and the overall hospital economic benefits by reducing the length of stay for ICU patients.8–13


We have and continue to support studies on IV in-line filtration devices. Some of these studies have contributed to national and international guidelines, such as, the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) and the Infusion Nursing Society (INS) which state that:


  • Consider filtration of solutions and medications to reduce particulate matter in critically ill patients that can cause thrombogenesis, impaired microcirculation, and alter immune response.”(INS 2021)16
  • “Healthcare organizations that do not filter Parenteral Nutrition (PN) admixtures or intravenous lipid emulsion (ILE) reevaluate these decisions and consider the small price of filters in comparison to increased morbidity and mortality that may result from not filtering ILE or PN.” (A.S.P.E.N. 2020) 15
  • “In-line filters are required for parenteral administration to reduce the potential for patient harm due to particulates, microprecipitates, microorganisms, and air emboli.” (A.S.P.E.N. 2014) 14


With a strong focus on patient safety and satisfaction, our expertise on IV in-line filtration devices and our customer and clinical body partnerships have help optimize infusion therapy worldwide.



  1. Myers G.J. (2017). Air in intravenous lines: a need to review old opinions. Perfusion; 32 (6): 432–435
  2. A. F. Merry A.F., Gargiulo D.A., Fry L.E. (2017). What are we injecting with our drugs? Anaesth Intensive Care; 45 (5): 539–542
  3. Holmes C.J., Kundsin R.B., Ausman R.K., Walter C.W. (1980). Potential hazards associated with microbial contamination of in-line filters during intravenous therapy. J Clin Microbiol;12 (6): 725–731
  4. Perez M., Maiguy-Foinard A., Barthélémy C., Décaudin B., Odou P. (2016). Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients. Pharm. Technol. Hosp. Pharm.; 1(2): 91–103
  5. Perez M. et al. (2018). Effectiveness of in-Line Filters to Completely Remove Particulate Contamination During a Pediatric Multidrug Infusion Protocol. Sci Rep; 8 (7714): 1 – 8
  6. Van Lingen R.A., Baerts W., Marquering A.C., Ruijs G.J. (2004). The use of in-line intravenous filters in sick newborn infants. Acta Paediatr; 93 (5): 658–62
  7. Richards C., Grassby P.F. (1994). A comparison of the endotoxin-retentive abilities of two '96–h' in-line intravenous filters. J Clin Pharm Ther;19 (3): 199–202
  8. Jack T. et al. (2012). In-line filtration reduces severe complications and length of stay on pediatric intensive care unit: a prospective, randomized, controlled trial. Intensive Care Med, 38, 1008–1016
  9. Boehne M.  et al.  (2013). In-line filtration minimizes organ dysfunction: New aspects from a prospective, randomized, controlled trial. BMC Pediatrics, 13 (21): 1–8
  10. Sasse M. et al. (2015). In-line Filtration Decreases Systemic Inflammatory Response Syndrome, Renal and Hematologic Dysfunction in Pediatric Cardiac Intensive Care Patients. Pediatr Cardiol; 36: 1270–1278
  11. Villa G. et al. (2018). In-Line Filtration Reduces Postoperative Venous Peripheral Phlebitis Associated With Cannulation: A Randomized Clinical Trial. Anesth Analg; 127(6): 1367–1374
  12. Unger-Hunt L. (2019). Reducing Risks and Generating Economic Benefits. Health Management; 19 (4): 286–287
  13. Schmitt E. et al. (2019). In-line filtration of intravenous infusion may reduce organ dysfunction of adult critical patients. Crit Care; 23(1): 373
  14. Ayers P. et al. (2014) A.S.P.E.N. Parenteral Nutrition Safety Consensus Recommendations. Journal of Parenteral and Enteral Nutrition; 38 (3): 296–333
  15. Worthington P. et al. (2020). Update on the Use of Filters for Parenteral Nutrition: An ASPEN Position Paper. Nutrition in Clinical Practice; 0 (0): 1 – 11
  16. Gorski L.A. et al. (2021). Infusion Therapy Standards of Practice, 8. Edition. J Infus Nurs; 01(44): S1–S224