Decreasing Therapeutic Protein Costs and Improving Process Safety
Chromatography is an essential part of the production of novel recombinant proteins, monoclonal and engineered antibodies, or viral vectors for gene therapy. Market pressure requires manufacturers to speed up development, simplify protein or viral vectors purification processes, and improve process economics. Consistent, scalable and validated purification platform solutions can fast track the purification process from R&D phases up to cGMP large-scale production.
There is a strong pressure to decrease therapeutic proteins market cost, and conventional capture chromatography, particularly Protein A chromatography media, can be a significant contributor to this cost. In addition, there is the cost and inconvenience of handling large buffer volumes and large processing hardware typically required for industrial scale protein production. Strategies to reduce cost and make more efficient use of the chromatography hardware and resin suggest running more but smaller batches ideally in a shorter timeframe. This can be achieved by using single-use chromatography equipment and resins, and/or processing chromatography in a continuous mode.
Chromatography performance can be dramatically increased and costs reduced with the right associated hardware and automation selected.
Continuous and/or single-use operation can be restricted to only the chromatography step or extended to the full process, from cell culture to final product, using stainless steel or single-use technologies. Pall’s integrated solutions allow you to select the best pathway for your process needs.
Overcoming the challenges of traditional buffer preparation
Join us on December 3 and find out how the increasing demands of buffer management and preparation can be addressed, saving floorspace and costs, and improving efficiency
The changing face of the biopharmaceutical industry has brought about an increased need for flexibility and adaptability, with developments in upstream processing resulting in higher product yields, and multi-product facilities becoming commonplace. With the ever-present call for manufacturers to reduce costs without compromising the essential facets of quality and safety, managing process buffers has become a very significant challenge.
Production demands are increasing, growing volumes of process buffer are required to fulfil production, floor space is at a premium, storage is overflowing into walkways, moving buffer from storage to processing is labor-intensive. If only there was another way…
Could there be a way to reduce buffer storage space, while meeting increasing demand?
Join our special event on Thursday December 3 and learn about an upcoming revolution in buffer management.