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Viral Clearance Using Anion Exchange Membranes

Scalable and ready to use solutions for impurity removal or capture of large molecules

Under appropriate conditions of ionic strength, anion exchange (AEX) sorbents or membranes can be used in negative or flow-through mode. This is done to remove virus contamination which binds to the surface of the membrane whilst the therapeutic molecule of interest, such as a monoclonal antibody (mAb), passes through the device. The plug and play nature of membrane chromatography devices makes them particularly convenient for this type of polishing step.

 

Typically employed at the end of a sequence of chromatography steps, anion exchange membrane capsules can also help reduce levels of Host Cell Protein (HCP) and DNA contamination as well as provide an orthogonal approach to viral clearance. Pall Biotech Mustang® Q capsules can be especially effective in this regard and have been employed successfully as part of an orthogonal strategy for virus safety in several industrial processes.

XT Acrodisc® Ion Exchange Chromatography Units with Mustang® Q and S membrane
Biotech

XT Acrodisc® Ion Exchange Chromatography Units with Mustang® Q and S membrane

Mustang® Membrane Chromatography Starter Kits
Biotech

Mustang® Membrane Chromatography Starter Kits

Mustang® Q XT Ion Exchange Chromatography Capsules to Optimize Your Scale Up
Biotech

Mustang® Q XT Ion Exchange Chromatography Capsules to Optimize Your Scale Up