Legionnaires’ Disease an Underestimated Problem

Legionnaires Disease is Likely Underdiagnosed - Learn About the Rise and Growth

May 28, 2021

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If Coronavirus has made anything clear, it is that infectious diseases are here to stay, can pop up at any moment, and every country that is unprepared for the threat will end up paying a steep price. One such underestimated problem is Legionnaires’ Disease, as a report by the European Centre for Disease Prevention and Control (ECDC) highlighted.1


What’s the problem?


Unfortunately, there is a lack of high-quality evidence and epidemiological data on infectious diseases. This makes it harder for healthcare experts to decide how best to allocate a country’s resources for the prevention and control of infectious diseases. 


What did the ECDC report set out to do?


The report estimated the burden of 31 diseases using “disability-adjusted life years” (DALYs) in the EEA area (EU + Norway, Iceland and Liechtenstein). DALYs describe the impact of “years lived with disability” (YLD) following the onset of a disease and of “years of life lost” due to premature mortality (YLL) compared with a standardized life expectancy.




Figure 1: Disability-adjusted life years (DALYs)  


What were the main results, and how does Legionnaire’s Disease fit in?

  1. Legionnaires’ Disease has a relatively low incidence, but it is also (and perhaps surprisingly) the disease with the 3rdhighest premature mortality, after rabies and diphtheria.
  2. In terms of mortality and incidence, Legionnaires’ Disease is the 5th largest disease after the “big four”  (Influenza, Tuberculosis,  HIV/AIDS,  Invasive Pneumococcal Disease) in terms of burden, with 10 annual DALYs per 100,000 populations (Figure 1). 
  3. Together with tuberculosis, HIV/AIDS and IPD, Legionnaires’ Disease is classed as a disease with a high population burden and a high individual burden (Figure 2).




Figure 2: Individual and population burden of 31 infectious disease

Scatterplot of the burden of selected infectious diseases in disability adjusted life years (DALYs) per case and DALYs per 100,000 population per year, European Union/European Economic. Area countries, 2009 to 2013. (Graphic adapted from Cassini et al.


What’s the status in the US?


In the United States, the number of cases of Legionnaires’ Disease reported to the CDC (Centers for Disease Control and Prevention) has been on the rise since 2000 and has grown by nearly nine times since then. Health departments reported nearly 10,000 cases of Legionnaires’ disease in the United States in 2018. However, because Legionnaires’ disease is likely underdiagnosed, this number may underestimate the true incidence.2


What’s the take home message? 


There is a significant burden associated with Legionnaires’ Disease in Europe. Countries would do well to allocate resources to combat the increasing spread of this disease in an adequate and timely manner. 



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Dr. Volker Luibl, MBA

Dr. Luibl is Pall accomplished Demand Generation Marketing Manager with extensive expertise in medical device and clinical science.
Dr. Luibl is Pall accomplished Demand Generation Marketing Manager with extensive expertise in medical device and clinical science.
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