Laboratory Ultrafiltration Membranes

Ultrafiltration (UF) is a membrane separation technique used to separate extremely small particles and dissolved molecules in fluids. The primary basis for separation is molecular size, although other factors such as molecule shape and charge can also play a role. Molecules larger than the membrane pores will be retained at the surface of the membrane (not in the polymer matrix as they are retained in microporous membranes) and concentrated during the ultrafiltration process. 

Compared to non-membrane processes (chromatography, dialysis, solvent extraction, or centrifugation), ultrafiltration: 

• Is far gentler to the molecules being processed  

• Does not require an organic extraction which may denature labile proteins maintains the ionic and pH milieu 

• Is fast and relatively inexpensive  

• Can be performed at low temperatures (for example, in the cold room) 

• Is very efficient and can simultaneously concentrate and purify molecules