Understanding the Sterile Filtration of Nanosuspensions
Finely colloid, biphasic, dispersed, and solid drug particles in an aqueous vehicle, size below 1 μm, without any matrix material, stabilized by surfactants and polymers for drug delivery applications.
- Increased drug solubility, absorption and bioavailability
- Reduces dosages and toxicity
- Various routes for administration; e.g. oil-in-water nanosuspensions such as liposomes and emulsions are used for topical oral and injectable drug delivery.
Manufacturing challenges for nanosuspensions
- Time consuming processes/intensive labor
- Process reproducibility and scale-up
- Control of size/size distribution
- Stability issues
- Appropriate characterisation of nanosuspensions throughout manufacturing is critical/important