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The advent of next generation sequencing techniques has enabled collection of unprecedented amounts of sequencing data in short spans of time. This has greatly contributed to our understanding of genomic and gene structure across many species and has also allowed us to gain much information about candidate genes for genetic disorders, cancer causing somatic mutations, and misexpression due to epigenetic changes. Validation of candidate genes can take place by genetically engineered disease models created in mammalian cell culture or whole animal models.
More of the workflows involved in these studies are carried out in high-throughput fashion aided by the use of multi-well DNA binding filter plates that allow larger numbers of genomic DNA samples to be obtained in parallel.
Technical Bulletin: Nucleases - Are They a Problem for NAB Nanosep® Centrifugal Devices?
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